UCLA Department of Chemistry and Biochemistry : UCLA Portal

Work Email Address:

yylin@chem.ucla.edu

Laboratory Address:

Laboratory
Young Hall 1040

Office Address:

Student Office
Young Hall 1032

Work Address:

Young Hall 2077C

Fax Number:

1 (310) 206-4038

Work Phone Number:

1 (310) 206-2856

Associate Professor
Chemistry and Biochemistry, Physical Chemistry

A Short Biography:

Professor Lin received his B.S. and M.S. degrees in physical chemistry at National Taiwan University, and PhD in physical chemistry in 1998 from University of California at Berkeley. After working as a Postdoctoral Research Associate in the Department of Chemistry, Princeton University, he joined the faculty at UCLA in 2001.

Awards and Honors:

Camille and Henry Dreyfus Teacher-Scholar Award ; Hanson-Dow Distinguished Teaching Award ; NSF CAREER Award ; UCLA Career Development Award ; Research Corp. Research Innovation Award ; Camille and Henry Dreyfus New Faculty Award

Research Interest:

The research theme of Prof. Lin's group is "channeling progress in fundamental spin physics and engineering into significant improvements in magnetic resonance spectroscopy and imaging with valuable applications in the chemical, biological and medical sciences, such as molecular imaging, early tumor/lesion detection, cellular imaging, and nano-medicine." His group encompasses a broad and balanced approach aimed at developing a solid theoretical understanding of new spin phenomena, sound methodology for improving sensitivity and contrast, and innovative applications to solve important biomedical challenges. Specifically, he and his group members currently focus on the following projects in theory, methodology, and applications.

(I) Theory: Quantum Theory for Dynamical Instability in Spin Hamiltonians;
(II) Theory: Nonlinear Spin Engineering with Multiple Feedback-Field Pulses;
(III) Methodology: Feedback-Enhanced MR for Contrast and Sensitivity Enhancement (Fig. 1);

Fig. 1. General spin amplification scheme for MR sensitivity and contrast enhancement (IV) Application: Early Tumor/Lesion Detection and Characterization (Fig. 2);

Fig. 2. Most cancers detected at stage 1 or 2 can be removed or cured; about 30% of those death caused by cancers can be avoided by early tumor detection. (V) Application: Nanoscience-Based Molecular Imaging and Cellular Imaging;
(VI) Application: Indirect Detection and Spin Amplification by Hyperpolarization, Diffusion, and Chemical Exchange.

Detailed Biography:

Prof. Lin completed his B.S. and M.S. in physical chemistry at National Taiwan University under the supervision of Prof. Lian-Pin Hwang, where they developed new mathematical methods for NMR diffusion study and spectral estimation. He pursued his PhD study with Prof. Alex Pines at University of California at Berkeley on spin dynamics in dipole-coupled many-spin systems in solid-state NMR. They generated new formulation and insights into the effects of quantum decoherence, bath fluctuations, and reaction fields on spin dynamics in quantum dissipative systems based on a spin-boson Hamiltonian. He carried out his postdoctoral research with Prof. Warren Warren in the Department of Chemistry, Princeton University, on nonlinear spin dynamics in solution NMR. They developed the theory and applications of intermolecular quantum coherences and discovered the existence of chaotic spin dynamics in routine experiments. Prof. Lin also holds a degree in Theology from China Evangelical Seminary.

Publications:

Y.-Y. Lin, S. Y. Huang Method and System for the Amplification of Nuclear Magnetic Resonance Imaging, , ; PCT/US07/61483.

S. Y. Huang, S. S. Yang, Y.-Y. Lin Sensitivity of Feedback-Enhanced MRI Contrast to Macroscopic and Microscopic Field Variations, Magn. Reson. Med., 2007; in press.

J. D. Walls, S. Y. Huang, Y.-Y. Lin Spin Amplification in Solution Magnetic Resonance Using Radiation Damping, J. Chem. Phys., 2007; (127): 054507.

S. Y. Huang, A. Chung, Y.-Y. Lin Visualizing Feedback-Enhanced Contrast in Magnetic Resonance Imaging, Concepts Magn. Reson. A , 2007; (in press): .

J. D. Walls, Y.-Y. Lin Constants of Motion in NMR Spectroscopy, Solid State Nucl. Magn. Reson., 2006; (29): 153��160.

S. Datta, S. Y. Huang, Y.-Y. Lin Contrast Enhancement by Feedback Fields in Magnetic Resonance Imaging, J. Phys. Chem. B, 2006; (110): 22071-22078.

S. Y. Huang, J. K. Furuyama, Y.-Y. Lin Designing Feedback-Based Contrast Enhancement for In Vivo Imaging, Magn. Reson. Mater. Phys. , 2006; (19): 333-346.

J. D. Walls, S. Y. Huang, Y.-Y. Lin , ???,??? J. Excitation of Magnetization Using a Modulated Radiation Damping Field, Phys. Chem. B, 2006; (110): 19985-19989.

S. Y. Huang, S. M. Wolahan, G. W. Mathern, D. J. Chute, M. Akhtari, S. T. Nguyen, M. N. Huynh, N. Salamon, Y.-Y. Lin Improving MRI Differentiation of Gray and White Matter in Epileptogenic Lesions Based on Nonlinear Feedback, Magn. Reson. Med., 2006; (56): 776-786.

S. Datta, S. Y. Huang, Y.-Y. Lin The Transient Dynamics Leading to Spin Turbulence in High-Field Solution Magnetic Resonance: A Numerical Study, J. Chem. Phys., 2006; (124): 154501.

E. W. Scamman, S. Y. Huang, M. G. Castro, Y.-Y. Lin Tracking Three-Dimensional Magnetization Trajectories by the Radiation Damping Feedback Field for Differential Spin Control, Chem. Phys. Lett., 2006; (427): 426-431.

S. Datta, S. Y. Huang, Y.-Y. Lin Understanding Spin Turbulence in Solution Magnetic Resonance Through Phase Space Dynamics and Instability, Concepts Magn. Reson. A, 2006; (28): 410-421.

S. Y. Huang, J. D. Walls, Y. Wang, W. S. Warren, Y.-Y. Lin Signal Irreproducibility in High-Field Solution Magnetic Resonance Experiments Caused by Spin Turbulence, J. Chem. Phys., 2004; (121): 6105��6109 .

S. Y. Huang, C. Anklin, J. D. Walls, Y.-Y. Lin Sizable Concentration-Dependent Frequency Shifts in Solution NMR Using Sensitive Probes, J. Am. Chem. Soc., 2004; (126): 15936???15937.

J. D. Walls, F. K. H. Phoa, Y.-Y. Lin Spin Dynamics at Very High Spin Polarization, Phys. Rev. B, 2004; (70): 174410 .

Yung-Ya Lin, Ph.D.