Elaine F. Reed, Ph.D.

Work Email Address: ereed@mednet.ucla.edu

Fax Number: (310) 206-3216
Office Phone Number: 310-825-6751
Work Phone Number: (310) 794-4943

Laboratory Address:
1000 Veteran Avenue
A5-38 Rehab
Los Angeles, CA 90095

Work Address:
1000 Veteran Ave.
15-20 Rehab
Los Angeles, CA 90095

Work

Position/Title

Professor, Pathology and Laboratory Medicine, Immunogenetics Center

Research Interests

Immunology - Immunogenetics; Immunology - Transplantation Biology

Education:

Degrees:
Ph.D., Columbia University , 1984

Lecturer:
Faculty of Medicine, University of Calgary, Rachel McKenna Memorial Lecturer

Honors and Awards:

National Kidney Registry, Excellence in Laboratory Support Award

2008 - American Society for Histocompatibility and Immunogenetics, Distinguished Scientist Award

1999 - 2001 Quality Assurance and Standards Committee, ASHI, Chair

1999 American Society for Histocompatibility and Immunogenetics, Council Member

1999 Clincal Histocompatibility Workshop Presentation Award

1997 - 2001 American Heart Association , Leach Foundation Research Scholar

1993 American Society for Histocompatibility and Immunogenetics, ASHI Scholar Award

1991 American Society for Histocompatibility and Immunogenetics, Young Investigator Award

Professional Societies:

2004 - American Society of Transplantation

2003 - International Society for Heart and Lung Transplantation

2000 - Transplantation Society

1999 - American Association of Immunologists

1999 - American Society for the Advancement of Science

1994 - American Board of Histocompatibility and Immunogenetics

1987 - American Society for Histocompatibility and Immunogenetics

1985 - American Society for the Advancement of Science

About

Dr. Elaine F. Reed is Professor of Pathology at the University of California, Los Angeles and Director of the UCLA Immunogenetics Center. She directs the research and clinical activities of the UCLA Immunogenetics Center and serves as Vice Chair of Research Services for the Department of Pathology. Dr. Reed�s research interests over the last 25 years have focused on mechanisms of antibody-mediated acute and chronic allograft rejection. Her recent research studies demonstrated that anti-HLA antibodies can contribute to the development of chronic rejection by triggering intracellular signaling cascades that culminate in endothelial cell and smooth muscle cell survival and proliferation. Her work has delineated the signaling pathways leading to cell proliferation and cell survival, providing the opportunity for the development of therapeutic strategies. Dr. Reed is an active member of the American Society for Histocompatibility and Immunogenetics, American Association of Immunologists, American Society of Transplantation, Federation of Clinical Immunology Societies, International Society for Heart and Lung Transplantation, and The Transplantation Society. She serves on the editorial boards of Human Immunology, American Journal of Transplantation and Transplant Immunology.

Publications

Qiuheng Zhang, Leonard W. Liang, David W. Gjertson, Charles Lassman, Alan H. Wilkinson, Elizabeth Kendrick, Thu-Phoung Pham, Gabriel M. Danovitch, H. Albin Gritsch, Elaine F. Reed, Development of Post Transplant Anti-Donor HLA Antibodies Is Associated With Acute Humoral Rejection and Early Graft Dysfunction. Transplantation. 2005; 79(5): 1-8.

Vincent R. Bonagura, Andrea Vambutas, James A. DeVoti, David W. Rosenthal, Bettie M. Steinberg, David W. Gjertson and Elaine F. Reed, HLA alleles, IFN-g responses to HPV-11 E6 and disease severity in patients with recurrent respiratory papillomatosis. Human Immunology. 2004; 65(8): 773-82.

Ralph D. Levinson, Robert F. See, Raja Rajalingam, Elaine F. Reed, Min S. Park, Narsing A. Rao, Gary N. Holland, HLA-DRB1 and -DQB1 Alleles in Mestizo Patients with Vogt-Koyanagi-Harada's Disease in Southern California". Human Immunology. 2004; 65(12): 1477-82.

Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson DW, Kappel See RF, Rao NA, Holland GN, Human Leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004; 138(4): 631-4.

Jatinderpal K. Kalsi, Jennifer Grossman, Jennifer. Kim, Peter Sieling, David A. Isenberg, Elaine F. Reed, Fanny M. Ebling, Mariane Linker-Israeli, Bevra H. Hahn, Peptides from antibodies to DNA elicit cytokine release from peripheral blood mononuclear cells of patients with systematic lupus erythematosus: relation of cytokine pattern to disease duration. Lupus. 2004; 13(7): 490-500.

Eric Lepin and Elaine F. Reed, Complement-independent alloantibody function in arteriosclerosis and accommodation. Current Opinion in Organ Transplantation. 2004; 9(1): 10-15.

Bonagura, VR Vambutas, A DeVoti, JA Rosenthal, DW Steinberg, BM Abramson, AL Shikowitz, MJ Gjertson, DW Reed, EF, HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis.. Human immunology. . 2004; 65(8): 773-82.

Lepin, EJ, Jin YP, Barswe SP, Rozengurt E, Reed, EF, HLA class I signal transduction is dependent on Rho GTPase and ROK. Biochem Biophys Res Commun. . 2004; 323(1): 213-217.

Levinson RD, Rajalingam R, Park MS, Reed EF, Gjertson Dw, Kappel PJ, See RF, Rao NA, Holland GN., Human leukocyte antigen A29 subtypes associated with birdshot retinochoroidopathy. Am J Ophthalmol. 2004; 138(4): 631-4.

Vambutas A, Bonagura VR, Reed EF, Ambramson AL, Mullooly V, DeVoti J, Gjertson D, Steinberg BM, Polymorphism of Transporter Associated with Antigen Presentation 1 as a Potential Determinant for Severity of Disease in Recurrent Respiratory Papillomatosis. Journal of Infectious Diseases. 2004; 189(5): 871-9.

Ralph D. Levinson, Min S. Park, Sarah M. Rikkers, Elaine F. Reed, Justine R. Smith, Tammy M. Martin, James T. Rosenbaum, C. Stephen Foster, Mark D. Sherman, and Gary N. Holland, Strong Associations between Specific HLA-DQ and HLA-DR Alleles and the Tubulointerstitial Nephritis and Uveitis Syndrome. Investigative Opthalmology & Visual Science. 2003; 44(2): 653-657.

Reed, EF, Signal transduction via MHC class I molecules in endothelial and smooth muscle cells.. Critical reviews in immunology. . 2003; 23(1-2): 109-28.

Zhang Xiaohai, Valenzuela Nicole M, Reed Elaine F, HLA class I antibody-mediated endothelial and smooth muscle cell activation.. Current opinion in organ transplantation. 2012; .

Ziegler Mary E, Souda Puneet, Jin Yi-Ping, Whitelegge Julian P, Reed Elaine F, Characterization of the endothelial cell cytoskeleton following HLA class I ligation.. PloS one. 2012; 7(1): e29472.

Li Fang, Zhang Xiaohai, Jin Yi-Ping, Mulder Arend, Reed Elaine F, Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase-dependent manner.. Human immunology. 2011; 72(12): 1150-9.

Ziegler Mary E, Chen Tingchao, LeBlanc James F, Wei Xuelian, Gjertson David W, Li Ker-Chau, Khalighi Mazdak A, Lassman Charles R, Veale Jeffrey L, Gritsch H Albin, Reed Elaine F, Apolipoprotein A1 and C-terminal fragment of α-1 antichymotrypsin are candidate plasma biomarkers associated with acute renal allograft rejection.. Transplantation. 2011; 92(4): 388-95.

Zhang Qiuheng, Cecka J Michael, Gjertson David W, Ge Ping, Rose Marlene L, Patel Jignesh K, Ardehali Abbas, Kobashigawa Jon A, Fishbein Michael C, Reed Elaine F, HLA and MICA: targets of antibody-mediated rejection in heart transplantation.. Transplantation. 2011; 91(10): 1153-8.

Zhang Xiaohai, Reed Elaine F, HLA Class I: An unexpected role in integrin β4 signaling in endothelial cells.. Human immunology. 2012; .

Lipshutz Gerald S, McGuire Suzanne, Zhu Qing, Ziman Alyssa, Davis Rebecca, Goldfinger Dennis, Reed Elaine F, Wilkinson Alan H, Danovitch Gabriel M, Pham Phuong-Thu, ABO blood type-incompatible kidney transplantation and access to organs.. Archives of surgery (Chicago, Ill. : 1960). 2011; 146(4): 453-8.

Yang Otto O, Lewis Martha J, Reed Elaine F, Gjertson David W, Kalilani-Phiri Linda, Mkandawire James, Helleringer Stéphane, Kohler Hans-Peter, Human leukocyte antigen class I haplotypes of human immunodeficiency virus-1-infected persons on Likoma Island, Malawi.. Human immunology. 2011; 72(10): 877-80.

Valenzuela Nicole M, Reed Elaine F, The link between major histocompatibility complex antibodies and cell proliferation.. Transplantation reviews (Orlando, Fla.). 2011; 25(4): 154-66.

Shah M.R., Starling R.C., Schwartz Longacre L., Mehra M.R, Working Group Participants. Collaborators: Barr M., Eisen H., Francis G., Fung J., Grady K., Jeevanandam V., Johnson M., Kfoury A., Kirklin J., Kobashigawa J., Kormos R., Madsen J., Mancini D., McManus B., O'Connor C., Pfeffer M., Pierson R. 3rd, Reed E., Salomon D., Steenbergen C., Stevenson L., Tracy L., Wang L., Heart transplantation research in the next decade--a goal to achieving evidence-based outcomes: National Heart, Lung, And Blood Institute Working Group. J Am Coll Cardiol.. 2012; 59(14): 1263-9.

Valenzuela N.M., Reed E.F. , HLA I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on isotype, by engaging FcyRs. Journal of Immunology. 2012; .

Mengel M., Campbell P., Gebel H., Randhawa P., Rodriguez R., Colvin R., Conway J., Hachem R., Halloran P., Keshavjee S., Nickerson P., Murphey C., O�Leary J., Reeve J., Tinckam K., Reed E. , Precision diagnostics in transplantation: from bench to bedside. Meeting Report: CST-AST 2012 joint session. American Journal of Transplantation. 2012; .

Vierra-Green C., Roe D., Hou L., Hurley C.K., Rajalingam R., Reed E.F., Lebedeva T., Yu N., Stewart M., Noreen H., Hollenbach J.A., Guethlein L., Wang T., Spellman S.R., Maiers M., Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals. PLoS One. 2012; .

Ziegler M.E., Jin Y.P., Young S.H., Rozengurt E., Reed E.F., Anti-HLA class I mediated stress fiber formation requires ERK 1/2 activation in the absence of an increase in intracellular CA2+ in human aortic endothelial cells. American Journal of Physiology - Cell Physiology. 2012; .

Valenzuela N.M., Hong L., Shen X., Gao F., Young S., Rozengurt E., Fishbein M., Kupiec-Weglinski J., Reed E.F. , Blockade of P-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo. American Journal of Transplantation. 2012; .

Melcher M., Baxter-Lowe L.A., Blosser C., Delmonico F., Gentry S., Hanto R., Knoll G., Leffell S., Leichtman A., Mast D., Nickerson P., Reed E.F., Rees M., Rodrigue J., Seqev D., Serur D., Dynamic challenges inhibiting optimal adoption of kidney paired donation: findings of a consensus conference. American Journal of Transplantation. 2012; .

Shino M.Y., Weigt S.S., Saggar R., Elashoff D., Derhovanessian A., Gregson A.L., Saggar R., Reed E.F., Kubak B.M., Lynch III J.P., Belerio J.A., Ardehali A., Ross D.J., Usefulness of immune monitoring in lung transplantation using ATP production in activated lymphocytes. Journal of Heart and Lung Transplantation. 2012; .

Patel Jignesh, Everly Matthew, Chang David, Kittleson Michelle, Reed Elaine, Kobashigawa Jon, Reduction of alloantibodies via proteasome inhibition in cardiac transplantation.. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2011; 30(12): 1320-6.

KEYWORDS

Transplantation Immunology, Immunogenetics