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Stephan R Targan, M.D.

Work Email Address: targans@cshs.org

Fax Number: 310-423-0224
Work Phone Number: 310-423-7723
310-917-3549

Mailing Address:
8700 Beverly Bl
BOX 950000, Rm 4063-Davis
Los Angeles, CA 90048

Work
Position/Title
Professor, Medicine
Director, Division of Gastrointestinal and Inflammatory Bowel Disease, Inflammatory Bowel Disease Center and Immunobiology Research institute

Research Interests

Microbiology/Infectious Diseases, Medicine - Gastroenterology


Education:

Degrees:
M.D., Johns Hopkins University, 1967 - 1971

B.A., Johns Hopkins University, 1963 - 1967


About

Stephan R. Targan, MD is Director of both the Inflammatory Bowel Disease Center and the Division of Gastroenterology at Cedars-Sinai Medical Center. He holds the Feintech Family Chair in Inflammatory Bowel Disease at Cedars-Sinai.

Board certified in internal medicine, gastroenterology and infectious disease, Dr. Targan has been awarded investigative grants from the National Institutes of Health (NIH) and the Crohn's and Colitis Foundation of America, as well as research contracts with numerous industry sponsors. His research has primarily focused on the genetic and immunopathologic mechanisms of inflammatory bowel disease.

Dr. Targan is a member of several professional organizations, including the American Gastroenterological Association, American Association of Physicians and American Society for Clinical Investigation. He has written extensively for such peer-reviewed publications as the New England Journal of Medicine, Journal of Immunology and Gastroenterology. Dr. Targan has also written numerous book chapters on the causes, effects and treatments of inflammatory bowel disease. He is the editor of the widely acclaimed textbook Inflammatory Bowel Disease: From Bench to Bedside.

Dr. Targan earned his bachelor's and medical degrees from Johns Hopkins University in Baltimore. He completed his internship and residency at Harbor-UCLA Medical Center, as well as a fellowship in infectious diseases. Dr. Targan also completed fellowships in gastroenterology and immunology at UCLA Medical Center.

Publications
Ippoliti Andrew, Devlin Shane, Mei Ling, Yang Huiying, Papadakis Konstantinos A, Vasiliauskas Eric A, McGovern Dermot P B, Abreu Maria T, Melmed Gil, Shaye Omid, Enayati Pedram, Chen Gary, Choi Jennifer, Taylor Kent, Landers Carol J, Rotter Jerome I, Targan Stephan R, Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease.. Inflammatory bowel diseases. 2010; 16(8): 1279-85.
Saruta Masayuki, Targan Stephan R, Mei Ling, Ippoliti Andrew F, Taylor Kent D, Rotter Jerome I, High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.. Inflammatory bowel diseases. 2009; 15(3): 321-7.
Michelsen Kathrin S, Thomas Lisa S, Taylor Kent D, Yu Qi T, Mei Ling, Landers Carol J, Derkowski Carrie, McGovern Dermot P B, Rotter Jerome I, Targan Stephan R, IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.. PloS one. 2009; 4(3): e4719.
Shih David Q, Kwan Lola Y, Chavez Valerie, Cohavy Offer, Gonsky Rivkah, Chang Elmer Y, Chang Christopher, Elson Charles O, Targan Stephan R, Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.. European journal of immunology. 2009; 39(11): 3239-50.
Saruta Masayuki, Michelsen Kathrin S, Thomas Lisa S, Yu Qi T, Landers Carol J, Targan Stephan R, TLR8-mediated activation of human monocytes inhibits TL1A expression.. European journal of immunology. 2009; 39(8): 2195-202.
Brewer Sarah, McPherson Michael, Fujiwara Daisuke, Turovskaya Olga, Ziring David, Chen Ling, Takedatsu Hidetoshi, Targan Stephan R, Wei Bo, Braun Jonathan, Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-D-glucose and positron emission tomography.. Gastroenterology. 2008; 135(3): 744-55.
Devlin Shane M, Yang Huiying, Ippoliti Andrew, Taylor Kent D, Landers Carol J, Su Xiaowen, Abreu Maria T, Papadakis Konstantinos A, Vasiliauskas Eric A, Melmed Gil Y, Fleshner Phillip R, Mei Ling, Rotter Jerome I, Targan Stephan R, NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives.. Gastroenterology. 2007; 132(2): 576-86.
Picornell Yoana, Mei Ling, Taylor Kent, Yang Huiying, Targan Stephan R, Rotter Jerome I, TNFSF15 is an ethnic-specific IBD gene.. Inflammatory bowel diseases. 2007; 13(11): 1333-8.
Cohavy Offer, Zhou Jaclyn, Ware Carl F, Targan Stephan R, LIGHT is constitutively expressed on T and NK cells in the human gut and can be induced by CD2-mediated signaling.. Journal of immunology (Baltimore, Md. : 1950). 2005; 174(2): 646-53.
Papadakis Konstantinos A, Prehn John L, Landers Carol, Han Qiwei, Luo Xia, Cha Stephanie C, Wei Ping, Targan Stephan R, TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells.. Journal of immunology (Baltimore, Md. : 1950). 2004; 172(11): 7002-7.
KEYWORDS
Humans, Crohn Disease, Female, Male, Adult, Inflammatory Bowel Diseases, Middle Aged, Aged, Adolescent, Colitis; Ulcerative, Animals, Intestinal Mucosa, Antibodies; Monoclonal, Genetic Predisposition to Disease, Tumor Necrosis Factor Ligand Superfamily Member 15, Child, Case-Control Studies, Polymorphism; Single, Nucleotide, Tumor Necrosis, Factor-alpha, Enzyme-Linked, Immunosorbent Assay