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David T. Wong, D.M.D., D.M.Sc.

Work Email Address: dtww@ucla.edu

Work Phone Number: (310) 206-3048

Mailing Address:
10833 Le Conte Avenue
73-017 CHS
Los Angeles, CA 90095

Work

Position/Title

Professor, Dentistry (Oral Biology & Medicine), Bioengineering

Associate Dean for Research, Dentistry (Oral Biology & Medicine)

Director, Dental Research Institute

Research Interests

Genetics - Genomics; Clinical Dentistry; Medicine - Diabetes; Medicine - Gastroenterology; Medicine - Oncology; Medicine - Pulmonary Diseases

Education:

Degrees:
D.M.Sc., Harvard

D.M.D.

Fellowship:
2010 American College of Dentists, Fellow

1982 Medical Research Council of Canada, Post-doctoral Research Fellowship

1981 American Dental Association, The Henry M. Thorton Fellowship

Academic Experience:
2008 Oregon Health & Science University, OCTRI Academy Visiting Professorship

Honors and Awards:

SCADA , The Alan J. Davis/SCADA Achievement Award

2011 The Forsyth Institute, Dr. Murray J. Gavel Clinical Research Award

2007 International Association of Dental Research, Saliva Researcher of the Year

2004 University of California at Los Angeles, School of Dentistry, Distinguished Faculty Award

2002 IADR Experimental Pathology & Medicine Research Award, Distinguished Scientist Award

2001 Columbia University, Frederick Birnberg Research Award

1999 American Student Dental Association, 25 Dental Visionaries

1993 Harvard School of Dental Medicine, Distinguished Faculty Award

1991 National Institute of Dental Research, Research Career Development Award

1988 National Institutes of Health, FIRST Award

1987 American Cancer Society, Cancer Research Scholar Award

1985 Harvard School of Dental Medicine, The James H. Shaw Award

1981 University of British Columbia, Roy Sofield Memorial Prize in Dentistry

1980 - University of British Columbia, Dr. Lorin O. Lind Memorial Scholarship

1979 - Simon Fraser University, Chemistry Book Award

1977 American Chemical Society, Undergraduate Award in Analytical Chemistry

Certifications:

Certification Type:
2010 Sigma Xi, George Bugliarello Prize (Best paper in American Scientist "Salivary Diagnostics", 2008 and 2009)

Certification Type:
2010 American Association for Dental Research, President

2008 American Association for Dental Research, Vice President

2007 American Academy of Oral Medicine, Honorary Membership

1981 Omicron Kappa Upsilon Dental Society

About

David T.W. Wong DMD, DMSc is Felix & Mildred Yip Endowed Professor and Associate Dean of Research and Director of the Dental Research Institute at UCLA. Dr. Wong is an active scientist in oral cancer and saliva diagnostics research. His research has been continuously funded by NIH since 1986. He has authored over 220 peer reviewed scientific publications. He is a fellow of the American Association for the Advancement of Sciences (AAAS), past member of the ADA Council of Scientific Affairs and the immediate past president of American Association of Dental Research (AADR).

Publications

Deshpande, Dai, Kim, Kim, Kimlin, Gao, Hendrich, Wong, CDK2AP1 is required for epigenetic silencing of OCT4 during murine embryonic stem cell differentiation.. The Journal of biological chemistry. 2008; .

Wei Fang, Wang Jianghua, Liao Wei, Zimmermann Bernhard G, Wong David T, Ho Chih-Ming, Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe.. Nucleic acids research. 2008; 36(11): e65.

Hu Zhanzhi, Zimmermann Bernhard G, Zhou Hui, Wang Jianghua, Henson Bradley S, Yu Weixia, Elashoff David, Krupp Guido, Wong David T, Exon-level expression profiling: a comprehensive transcriptome analysis of oral fluids.. Clinical chemistry. 2008; 54(5): 824-32.

Deshpande Amit M, Wong David T, Molecular mechanisms of head and neck cancer.. Expert review of anticancer therapy. 2008; 8(5): 799-809.

Tan Winny, Sabet Leyla, Li Yang, Yu Tianwei, Klokkevold Perry R, Wong David T, Ho Chih-Ming, Optical protein sensor for detecting cancer markers in saliva.. Biosensors & bioelectronics. 2008; 24(2): 266-71.

Wong, D.T. , Saliva Diagnostics. American Scientist. 2008; .

Zimmermann Bernhard G, Wong David T, Salivary mRNA targets for cancer diagnostics.. Oral oncology. 2008; 44(5): 425-9.

Hu Shen, Arellano Martha, Boontheung Pinmanee, Wang Jianghua, Zhou Hui, Jiang Jiang, Elashoff David, Wei Roger, Loo Joseph A, Wong David T, Salivary proteomics for oral cancer biomarker discovery.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008; 14(19): 6246-52.

Hu, Zhou, Jiang, Wang, Elashoff, Gorr, Michie, Spijkervet, Bootsma, Kallenberg, Vissink, Horvath, Wong, Systems biology analysis of sj�gren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands.. Arthritis and rheumatism. 2008; 60(1): 81-92.

Denny Paul, Hagen Fred K, Hardt Markus, Liao Lujian, Yan Weihong, Arellanno Martha, Bassilian Sara, Bedi Gurrinder S, Boontheung Pinmannee, Cociorva Daniel, Delahunty Claire M, Denny Trish, Dunsmore Jason, Faull Kym F, Gilligan Joyce, Gonzalez-Begne Mireya, Halgand Fr�d�ric, Hall Steven C, Han Xuemei, Henson Bradley, Hewel Johannes, Hu Shen, Jeffrey Sherry, Jiang Jiang, Loo Joseph A, Ogorzalek Loo Rachel R, Malamud Daniel, Melvin James E, Miroshnychenko Olga, Navazesh Mahvash, Niles Richard, Park Sung Kyu, Prakobphol Akraporn, Ramachandran Prasanna, Richert Megan, Robinson Sarah, Sondej Melissa, Souda Puneet, Sullivan Mark A, Takashima Jona, Than Shawn, Wang Jianghua, Whitelegge Julian P, Witkowska H Ewa, Wolinsky Lawrence, Xie Yongming, Xu Tao, Yu Weixia, Ytterberg Jimmy, Wong David T, Yates John R, Fisher Susan J, The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions.. Journal of proteome research. 2008; 7(5): 1994-2006.

Ye Hui, Yu Tianwei, Temam Stephane, Ziober Barry L, Wang Jianguang, Schwartz Joel L, Mao Li, Wong David T, Zhou Xiaofeng, Transcriptomic dissection of tongue squamous cell carcinoma.. BMC genomics. 2008; 9(3): 69.

Yu, T. Ye, H. Sun, W. Li, K. C. Chen, Z. Jacobs, S. Bailey, D. K. Wong, D. T. Zhou, X. , A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array. BMC Bioinformatics. 2007; 8(1): 145.

Park, N. J. Zhou, X. Yu, T. Brinkman, B. M. Zimmermann, B. G. Palanisamy, V. Wong, D. T. , Characterization of salivary RNA by cDNA library analysis. Arch Oral Biol. 2007; 52: 30-35.

Hu, S. Yu, T. Xie, Y. Yang, Y. Li, Y. Zhou, X. Tsung, S. Loo, R. R. Loo, J. R. Wong, D. T. , Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry. Cancer Genomics Proteomics. 2007; 4(2): 55-64.

Hu Shen, Yu Tianwei, Xie Yongming, Yang Yanan, Li Yang, Zhou Xiaofeng, Tsung Stephanie, Loo Rachel R, Loo Joseph R, Wong David T, Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry.. Cancer genomics & proteomics. 2007; 4(2): 55-64.

Molinolo Alfredo A, Hewitt Stephen M, Amornphimoltham Panomwat, Keelawat Somboon, Rangdaeng Samraeung, Meneses Garc�a Abelardo, Raimondi Ana R, Jufe Rafael, Itoiz Mar�a, Gao Yan, Saranath Dhananjaya, Kaleebi George S, Yoo George H, Leak Lee, Myers Ernest M, Shintani Satoru, Wong David, Massey H Davis, Yeudall W Andrew, Lonardo Fulvio, Ensley John, Gutkind J Silvio, Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(17): 4964-73.

Ye, H. Pungpravat, N. Huang, B. L. Muzio, L. L. Mariggio, M. A. Chen, Z. Wong, D. T. Zhou, X. , Genomic assessments of the frequent loss of heterozygosity region on 8p21.3 approximately p22 in head and neck squamous cell carcinoma. Cancer Genet Cytogenet. 2007; 176(2): 100-6.

Zimmermann, B. G. Park, N. J. Wong, D. T. , Genomic targets in saliva. Ann N Y Acad Sci. 2007; 1098: 184-91.

Zimmermann Bernhard G, Park Noh Jin, Wong David T, Genomic targets in saliva.. Annals of the New York Academy of Sciences. 2007; 1098(4): 184-91.

Hu, S. Loo, J. A. Wong, D. T. , Human saliva proteome analysis and disease biomarker discovery. Expert Rev Proteomics. 2007; 4(4): 531-8.

Hu Shen, Loo Joseph A, Wong David T, Human saliva proteome analysis.. Annals of the New York Academy of Sciences. 2007; 1098(4): 323-9.

Hu, S. Yen, Yun Ann, David Wong, D.T. , Implications of salivary proteomics for cancer drug discovery. Drug Discovery. 2007; 12: 911-916.

Hu, S. Wong, D. T. , Oral cancer proteomics. Curr Opin Mol Ther. 2007; 9(5): 467-76.

Gau, V. Wong, D. , Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform. Ann N Y Acad Sci. 2007; 1098: 401-10.

Gau Vincent, Wong David, Oral fluid nanosensor test (OFNASET) with advanced electrochemical-based molecular analysis platform.. Annals of the New York Academy of Sciences. 2007; 1098(4): 401-10.

Whitelegge Mario A, Zabrouskov Mario A, Halgand Mario A, Souda Mario A, Bassilian Mario A, Yan Mario A, Wolinsky Mario A, Loo Mario A, Wong Mario A, Faull Mario A, Protein-Sequence Polymorphisms and Post-translational Modifications in Proteins from Human Saliva using Top-Down Fourier-transform Ion Cyclotron Resonance Mass Spectrometry.. International journal of mass spectrometry. 2007; 268(2-3): 190-197.

Whitelegge, Julian Zabrouskov, Vlad Halgrand, F. Souda, P. Bassilian, S. Yan, W. Wolinsky, L. Loo, J. A. Wong, D.T. Faull, K. , Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top-down Fourier-transform ion cyclotron resonance mass spectrometry. International Journal of Mass Spectrometry. 2007; 268: 190-197.

Park, N. J. Yu, T. Nabili, V. Brinkman, B. M. Henry, S. Wang, J. Wong, D. T. , RNAprotect Saliva: An Optimal Room- Temperature Stabilization Reagent for the Salivary Transcriptome. Clin Chem. 2007; 52(12): 2303-4.

Zimmermann, B. G. Wong, D. T. , Salivary mRNA targets for cancer diagnostics. Oral Oncol. 2007; .

Hu, S. Wang, J. Meijer, J. Ieong, S. Xie, Y. Yu, T. Zhou, H. Henry, S. Vissink, A. Pijpe, J. Kallenberg, C. Elashoff, D. Loo, J. A. Wong, D. T. , Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome. Arthritis Rheum. 2007; 56(11): 3588-3600.

Hu Shen, Wang Jianghua, Meijer Jiska, Ieong Sonya, Xie Yongming, Yu Tianwei, Zhou Hui, Henry Sharon, Vissink Arjan, Pijpe Justin, Kallenberg Cees, Elashoff David, Loo Joseph A, Wong David T, Salivary proteomic and genomic biomarkers for primary Sj�gren's syndrome.. Arthritis and rheumatism. 2007; 56(11): 3588-600.

Zhou X, Yu T, Cole SW, Wong DT, Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer. Expert Rev Mol Diagn. 2006; 6(1): 39-50.

Park NJ, Li Y, Yu T, Brinkman BM, Wong DT , Characterization of RNA in saliva. Clin Chem. 2006; 52(6): 988-94.

Brinkman BM, Wong DT, Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol. 2006; 18(3): 228-233.

Figueiredo ML, Dayan S, Kim Y, McBride J, Kupper TS, Wong DT, Expression of cell-cycle regulator CDK2-associating protein 1 (p12(CDK2AP1)) in transgenic mice induces testicular and ovarian atrophy in vivo. Mol Reprod Dev. 2006; .

St John MA, Abemayor E, Wong DT, Recent new approaches to the treatment of head and neck cancer. Anticancer Drugs. 2006; 17(4): 365-75.

Wong DT, Salivary diagnostics powered by nanotechnologies, proteomics and genomics. J American Dental Association. 2006; 137: 313-321.

Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT, Serum Circulating Human mRNA Profiling and Its Utility for Oral Cancer Detection. Journal Clinical Oncology. 2006; In press.

Yang CYm, Brooks E, Li Y, Denny P, Ho CM, Qi F, Shi W, Wolinsky L, Wu B, Wong DT, Montemagno CD, Detection of picomolar levels of interleukin-8 in human saliva by SPR. Lab Chip. 2005; 5(10): 1017-23.

Zhou X, Jordan RC, Li Y, Huang BL, Wong DT, Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions. Cancer Genet Cytogenet. 2005; 161(1): 86-9.

Zhou X, Cole SW, Rao NP, Cheng Z, Li Y, McBride J, Wong DT, Identification of discrete chromosomal deletion by binary recursive partitioning of microarray differential expression data. J Med Genet. 2005; 42(5): 416-9.

Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT, Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics. 2005; 5(6): 1714-28.

Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DT, Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays. Cancer Genet Cytogenet. 2005; 159(1): 53-7.

Li Y, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Wolinsky L, Wong DT, The Oral Fluid MEMS/NEMS Chip (OFMNC): diagnostic and translational applications. Adv Dent Res. 2005; 18(1): 3-5.

Zhou X, Jordan RCK, Mok S, Birrer MJ, Wong DT , DNA Copy Number Abnormality of Oral Squamous Cell Carcinoma Detected by cDNA. Cancer Genetics & Cytogenetics. 2004; 151: 90-92.

Zhou X, Cole SW, Hu S, Wong DT, Detection of DNA copy number abnormality by microarray expression analysis. Hum Genet. 2004; 114(5): 464-467.

Hu S, Denny P, Xie Y, Loo JA, Wolinsky LE, Li Y, McBride J, Ogorzalek Loo RR, Navazesh M, Wong DT, Differentially expressed protein markers in human submandibular and sublingual secretions. Int J Oncol. 2004; 25(5): 1423-30.

Shintani S, Ishikawa T, Nonaka T, Li C, Nakashiro K, Wong DT, Hamakawa H, Growth-regulated oncogene-1 expression is associated with angiogenesis and lymph node metastasis in human oral cancer. Oncology. 2004; 66(4): 316-22.

St John M, Li Y, Zhou X, Denny P, Ho CM Montemagno CD, Shi W, Qi F, Wu B, Jordan RCK, Sinha U, Park NH Abemayor E, Wong DTW, IL-6 and IL-8: Potential biomarkers for oral cavity and oropharyngeal SCCA. Arch Otolaryngol Head Neck Surg. 2004; 130: 929-935.

Buajeeb W, Zhang X, Ohyam H, Han D, Surarita R, Kim Y, Wong DTW, Interaction of the CDK2 associated protein-1, p12DOC-1/CDK2AP1, with its homolog, p14DOC-1R. Biochem Biophys Res Comm. 2004; 315: 998-1003.

Figueiredo ML, Kim YK, Zhou XZ, Myers JN, Wong DDT, Molecular Mechanisms of Head and Neck Cancer. Mechanism of Diseases. 2004; 1: 273-281.

Kreth JK, Hagerman E, Tam K, Merritt J, Wong D, Wu B M, Myung NV, Shi W, Qi F, Quantitative Analyses of Streptococcus mutans Biofilms Formed under Different Sucrose Concentrations by using quartz crystal microbalance and microjet impingement.. Biofilm. 2004; 1: 277-284.

Li Y, Zhou X, St John MA, Wong DT, RNA Profiling of Cell-free Saliva Using Microarray Technology. J Dent Res. 2004; 83(3): 199-203.

Zhou X, Li C, Mok S, Chen Z, Wong DTW, Whole Genome LOH Profiling on Oral Squamous Cell Carcinoma by High-Density SNP Array. Cancer Genet & Cytogenet. 2004; 151: 82-84.

KEYWORDS

Mouth Neoplasms, Humans, Neoplastic Stem Cells, Signal Transduction, Tumor Suppressor Proteins, Epigenesis; Genetic, Embryonic Stem Cells, Carcinoma; Squamous Cell, Cell Cycle Checkpoints, Cell Differentiation, Cyclin-Dependent Kinases, Animals