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Bio:
Christopher Evans received his Ph.D. from Imperial College London, conducting his thesis research on endorphins and enkephalins, at the Medical Research Council Institute in Mill Hill. After a postdoctoral fellowship at Stanford University, Dr. Evans joined the UCLA faculty in the Department of Psychiatry and Biobehavioral Science. His research accomplishments have included identification of a number of novel endogenous opioid peptides and the cloning of the first opioid receptor. Dr. Evans is currently Director of the UCLA Brain Research Institute and the Stefan Hatos Professor directing the Shirley and Stefan Hatos Center for Neurophamacology in the UCLA Semel Institute. Dr. Evans is also director of a NIH-funded center - The Center for Opioid Receptors and Drugs of Abuse or CSORDA. CSORDA, now in its 19th year of continuous NIH funding, aims to understand the action of opioid drugs such as morphine and heroin at the molecular, cellular and behavioral levels.
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Publications:
Gioiosa, L. Chen, X. Watkins, R. Klanfer, N. Bryant, C. D. Evans, C. J. Arnold, A. P. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice.
Horm Behav.
2008; 53( 1):
124-30.
Walwyn, W. Evans, C. J. Hales, T. G. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons.
J Neurosci.
2007; 27( 19):
5092-104.
Kho, S. T. Lopez, I. A. Evans, C. Ishiyama, A. Ishiyama, G. Immunolocalization of orphanin FQ in rat cochlea.
Brain Res.
2006; 1113( 1):
146-52.
Bryant, C. D. Roberts, K. W. Byun, J. S. Fanselow, M. S. Evans, C. J. Morphine analgesic tolerance in 129P3/J and 129S6/SvEv mice.
Pharmacol Biochem Behav.
2006; 85( 4):
769-79.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.
Neuroscience.
2006; 142( 2):
493-503.
Bryant, C. D. Eitan, S. Sinchak, K. Fanselow, M. S. Evans, C. J. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice.
Am J Physiol Regul Integr Comp Physiol.
2006; 291( 2):
R315-26.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons.
Mol Pharmacol.
2005; 68( 6):
1688-98.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice.
Neuroscience.
2004; 123( 1):
111-21.
Eitan, S. Bryant, C. D. Saliminejad, N. Yang, Y. C. Vojdani, E. Keith, D., Jr. Polakiewicz, R. Evans, C. J. Brain region-specific mechanisms for acute morphine-induced mitogen-activated protein kinase modulation and distinct patterns of activation during analgesic tolerance and locomotor sensitization.
J Neurosci.
2003; 23( 23):
8360-9.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J. Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.
J Neurosci.
2003; 23( 32):
10331-7.
Charles, A. C. Mostovskaya, N. Asas, K. Evans, C. J. Dankovich, M. L. Hales, T. G. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory.
Mol Pharmacol.
2003; 63( 1):
89-95.
Li, Y. Eitan, S. Wu, J. Evans, C. J. Kieffer, B. Sun, X. Polakiewicz, R. D. Morphine induces desensitization of insulin receptor signaling.
Mol Cell Biol.
2003; 23( 17):
6255-66.
Reeve, J. R., Jr. Keire, D. A. Coskun, T. Green, G. M. Evans, C. Ho, F. J. Lee, T. D. Davis, M. T. Shively, J. E. Solomon, T. E. Synthesis of biologically active canine CCK-58.
Regul Pept.
2003; 113( 1-3):
71-7.
Arjomand, J. Cole, S. Evans, C. J. Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells.
J Neuroimmunol.
2002; 130( 1-2):
100-8.
Zaki, P. A. Keith, D. E., Jr. Thomas, J. B. Carroll, F. I. Evans, C. J. Agonist-, antagonist-, and inverse agonist-regulated trafficking of the delta-opioid receptor correlates with, but does not require, G protein activation.
J Pharmacol Exp Ther.
2001; 298( 3):
1015-20.
Arjomand, J. Evans, C. J. Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor.
J Neurochem.
2001; 77( 3):
720-9.
Ishiyama, A. Ishiyama, G. Baloh, R. W. Evans, C. J. Heroin-induced reversible profound deafness and vestibular dysfunction.
Addiction.
2001; 96( 9):
1363-4.
Evans, C. J. Agonist selective mu-opioid receptor trafficking in rat central nervous system.
Mol Psychiatry.
2000; 5( 2):
121.
Piros, E. T. Charles, R. C. Song, L. Evans, C. J. Hales, T. G. Cloned delta-opioid receptors in GH(3) cells inhibit spontaneous Ca(2+) oscillations and prolactin release through K(IR) channel activation.
J Neurophysiol.
2000; 83( 5):
2691-8.
Melone, M. Brecha, N. C. Sternini, C. Evans, C. Conti, F. Etorphine increases the number of mu-opioid receptor-positive cells in the cerebral cortex.
Neuroscience.
2000; 100( 3):
439-43.
Zaki, P. A. Keith, D. E., Jr. Brine, G. A. Carroll, F. I. Evans, C. J. Ligand-induced changes in surface mu-opioid receptor number: relationship to G protein activation?.
J Pharmacol Exp Ther.
2000; 292( 3):
1127-34.
Rabizadeh, S. Ye, X. Sperandio, S. Wang, J. J. Ellerby, H. M. Ellerby, L. M. Giza, C. Andrusiak, R. L. Frankowski, H. Yaron, Y. Moayeri, N. N. Rovelli, G. Evans, C. J. Butcher, L. L. Nolan, G. P. Assa-Munt, N. Bredesen, D. E. Neurotrophin dependence domain: a domain required for the mediation of apoptosis by the p75 neurotrophin receptor.
J Mol Neurosci.
2000; 15( 3):
215-29.
Charles, A. C. Piros, E. T. Evans, C. J. Hales, T. G. L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells.
J Biol Chem.
1999; 274( 11):
7508-15.
Lo, E. H. Pierce, A. R. Matsumoto, K. Kano, T. Evans, C. J. Newcomb, R. Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion.
Neuroscience.
1998; 83( 2):
449-58.
Monteillet-Agius, G. Fein, J. Anton, B. Evans, C. J. ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing.
J Comp Neurol.
1998; 399( 3):
373-83.
Murray, S. R. Evans, C. J. von Zastrow, M. Phosphorylation is not required for dynamin-dependent endocytosis of a truncated mutant opioid receptor.
J Biol Chem.
1998; 273( 39):
24987-91.
Unterwald, E. M. Anton, B. To, T. Lam, H. Evans, C. J. Quantitative immunolocalization of mu opioid receptors: regulation by naltrexone.
Neuroscience.
1998; 85( 3):
897-905.
Keith, D. E. Anton, B. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Monteillet-Agius, G. Stewart, P. L. Evans, C. J. von Zastrow, M. mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.
Mol Pharmacol.
1998; 53( 3):
377-84.
Rocha, L. L. Evans, C. J. Maidment, N. T. Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis.
J Neurochem.
1997; 68( 2):
616-24.
Yu, T. P. Fein, J. Phan, T. Evans, C. J. Xie, C. W. Orphanin FQ inhibits synaptic transmission and long-term potentiation in rat hippocampus.
Hippocampus.
1997; 7( 1):
88-94.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T. Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways.
J Neurosci.
1997; 17( 19):
7471-9.
Gylys, K. H. Tran, N. Magendzo, K. Zaki, P. Evans, C. J. cAMP decreases steady-state levels of delta-opioid receptor mRNA in NG108-15 cells.
Neuroreport.
1997; 8( 9-10):
2369-72.
Sternini, C. Spann, M. Anton, B. Keith, D. E., Jr. Bunnett, N. W. von Zastrow, M. Evans, C. Brecha, N. C. Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.
Proc Natl Acad Sci U S A.
1996; 93( 17):
9241-6.
Anton, B. Fein, J. To, T. Li, X. Silberstein, L. Evans, C. J. Immunohistochemical localization of ORL-1 in the central nervous system of the rat.
J Comp Neurol.
1996; 368( 2):
229-51.
Zhu, J. Yin, J. Law, P. Y. Claude, P. A. Rice, K. C. Evans, C. J. Chen, C. Yu, L. Liu-Chen, L. Y. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain.
J Biol Chem.
1996; 271( 3):
1430-4.
Tian, J. Clare-Salzler, M. Herschenfeld, A. Middleton, B. Newman, D. Mueller, R. Arita, S. Evans, C. Atkinson, M. A. Mullen, Y. Sarvetnick, N. Tobin, A. J. Lehmann, P. V. Kaufman, D. L. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice.
Nat Med.
1996; 2( 12):
1348-53.
Keith, D. E. Murray, S. R. Zaki, P. A. Chu, P. C. Lissin, D. V. Kang, L. Evans, C. J. von Zastrow, M. Morphine activates opioid receptors without causing their rapid internalization.
J Biol Chem.
1996; 271( 32):
19021-4.
Li, X. Keith, D. E., Jr. Evans, C. J. Mu opioid receptor-like sequences are present throughout vertebrate evolution.
J Mol Evol.
1996; 43( 3):
179-84.
Johnson, J. Chen, T. K. Rickman, D. W. Evans, C. Brecha, N. C. Multiple gamma-Aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina.
J Comp Neurol.
1996; 375( 2):
212-24.
Li, X. Keith, D. E., Jr. Evans, C. J. Multiple opioid receptor-like genes are identified in diverse vertebrate phyla.
FEBS Lett.
1996; 397( 1):
25-9.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr. Opioid peptide release and mu-receptor binding during amygdala kindling in rats: regional discordances.
Epilepsy Res Suppl.
1996; 12(number):
215-28.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
Epilepsy Res.
1996; 26( 1):
105-13.
Trapaidze, N. Keith, D. E. Cvejic, S. Evans, C. J. Devi, L. A. Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization.
J Biol Chem.
1996; 271( 46):
29279-85.
Befort, K. Tabbara, L. Bausch, S. Chavkin, C. Evans, C. Kieffer, B. The conserved aspartate residue in the third putative transmembrane domain of the delta-opioid receptor is not the anionic counterpart for cationic opiate binding but is a constituent of the receptor binding site.
Mol Pharmacol.
1996; 49( 2):
216-23.
Piros, E. T. Prather, P. L. Law, P. Y. Evans, C. J. Hales, T. G. Voltage-dependent inhibition of Ca2+ channels in GH3 cells by cloned mu- and delta-opioid receptors.
Mol Pharmacol.
1996; 50( 4):
947-56.
Piros, E. T. Prather, P. L. Loh, H. H. Law, P. Y. Evans, C. J. Hales, T. G. Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells.
Mol Pharmacol.
1995; 47( 5):
1041-9.
Milligan, C. E. Webster, L. Piros, E. T. Evans, C. J. Cunningham, T. J. Levitt, P. Induction of opioid receptor-mediated macrophage chemotactic activity after neonatal brain injury.
J Immunol.
1995; 154( 12):
6571-81.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T. Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release.
Neuroreport.
1995; 6( 8):
1093-6.
Prather, P. L. McGinn, T. M. Erickson, L. J. Evans, C. J. Loh, H. H. Law, P. Y. Ability of delta-opioid receptors to interact with multiple G-proteins is independent of receptor density.
J Biol Chem.
1994; 269( 33):
21293-302.
Law, P. Y. McGinn, T. M. Wick, M. J. Erikson, L. J. Evans, C. Loh, H. H. Analysis of delta-opioid receptor activities stably expressed in CHO cell lines: function of receptor density?.
J Pharmacol Exp Ther.
1994; 271( 3):
1686-94.
Mastrogiacomo, A. Evans, C. J. Gundersen, C. B. Antipeptide antibodies against a Torpedo cysteine-string protein.
J Neurochem.
1994; 62( 3):
873-80.
Kaufman, D. L. Xia, Y. R. Keith, D. E., Jr. Newman, D. Evans, C. J. Lusis, A. J. Localization of the delta-opioid receptor gene to mouse chromosome 4 by linkage analysis.
Genomics.
1994; 19( 2):
405-6.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr. Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation.
Exp Neurol.
1994; 126( 2):
277-83.
Reeve, J. R., Jr. Eysselein, V. E. Ho, F. J. Chew, P. Vigna, S. R. Liddle, R. A. Evans, C. Natural and synthetic CCK-58. Novel reagents for studying cholecystokinin physiology.
Ann N Y Acad Sci.
1994; 713(number):
11-21.
Liu, Y. Schweitzer, E. S. Nirenberg, M. J. Pickel, V. M. Evans, C. J. Edwards, R. H. Preferential localization of a vesicular monoamine transporter to dense core vesicles in PC12 cells.
J Cell Biol.
1994; 127( 5):
1419-33.
Von Zastrow, M. Keith, D. E., Jr. Evans, C. J. Agonist-induced state of the delta-opioid receptor that discriminates between opioid peptides and opiate alkaloids.
Mol Pharmacol.
1993; 44( 1):
166-72.
Keith, D. E., Jr. Anton, B. Evans, C. J. Characterization and mapping of a delta opioid receptor clone from NG108-15 cells.
Proc West Pharmacol Soc.
1993; 36(number):
299-306.
Ruppert, C. Sandrasagra, A. Anton, B. Evans, C. Schweitzer, E. S. Tobin, A. J. Rat-1 fibroblasts engineered with GAD65 and GAD67 cDNAs in retroviral vectors produce and release GABA.
J Neurochem.
1993; 61( 2):
768-71.
Evans, C. J. Keith, D. E., Jr. Morrison, H. Magendzo, K. Edwards, R. H. Cloning of a delta opioid receptor by functional expression.
Science.
1992; 258( 5090):
1952-5.
Maidment, N. T. Siddall, B. J. Rudolph, V. R. Erdelyi, E. Evans, C. J. Dual determination of extracellular cholecystokinin and neurotensin fragments in rat forebrain: microdialysis combined with a sequential multiple antigen radioimmunoassay.
Neuroscience.
1991; 45( 1):
81-93.
Wagner, J. J. Evans, C. J. Chavkin, C. Focal stimulation of the mossy fibers releases endogenous dynorphins that bind kappa 1-opioid receptors in guinea pig hippocampus.
J Neurochem.
1991; 57( 1):
333-43.
Madden, J. th Evans, C. J. Tyler, A. N. Esch, F. S. Bohlen, P. Makk, G. Weber, E. Isolation and characterization of opioid peptides from rabbit cerebellum.
J Neurochem.
1991; 56( 6):
1914-20.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J. Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis.
J Neurochem.
1991; 56( 6):
1980-4.
Abood, M. E. Eberwine, J. H. Erdelyi, E. Evans, C. J. Regulation of both preproenkephalin mRNA and its derived opioids by haloperidol--a method for measurement of peptides and mRNA in the same tissue extract.
Brain Res Mol Brain Res.
1990; 8( 3):
243-8.
Tecott, L. H. Rubenstein, J. L. Paxinos, G. Evans, C. J. Eberwine, J. H. Valentino, K. L. Developmental expression of proenkephalin mRNA and peptides in rat striatum.
Brain Res Dev Brain Res.
1989; 49( 1):
75-86.
Feistner, G. J. Hojrup, P. Evans, C. J. Barofsky, D. F. Faull, K. F. Roepstorff, P. Mass spectrometric charting of bovine posterior/intermediate pituitary peptides.
Proc Natl Acad Sci U S A.
1989; 86( 16):
6013-7.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J. Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo.
Neuroscience.
1989; 33( 3):
549-57.
Stevens, K. E. Leslie, F. M. Evans, C. J. Belluzzi, J. D. Stein, L. BAM-18: analgesia, hyperalgesia and locomotor effects.
Neuropeptides.
1988; 12( 1):
21-7.
Eberwine, J. H. Barchas, J. D. Hewlett, W. A. Evans, C. J. Isolation of enzyme cDNA clones by enzyme immunodetection assay: isolation of a peptide acetyltransferase.
Proc Natl Acad Sci U S A.
1987; 84( 5):
1449-53.
Boarder, M. R. Evans, C. Adams, M. Erdelyi, E. Barchas, J. D. Peptide E and its products, BAM 18 and Leu-enkephalin, in bovine adrenal medulla and cultured chromaffin cells: release in response to stimulation.
J Neurochem.
1987; 49( 6):
1824-32.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M. Pharmacological properties of a proenkephalin A-derived opioid peptide: BAM 18.
Eur J Pharmacol.
1987; 138( 3):
359-66.
Lorenz, R. G. Tyler, A. N. Faull, K. F. Makk, G. Barchas, J. D. Evans, C. J. Characterization of endorphins from the pituitary of the spiny dogfish Squalus acanthias.
Peptides.
1986; 7( 1):
119-26.
Bartolome, J. V. Bartolome, M. B. Daltner, L. A. Evans, C. J. Barchas, J. D. Kuhn, C. M. Schanberg, S. M. Effects of beta-endorphin on ornithine decarboxylase in tissues of developing rats: a potential role for this endogenous neuropeptide in the modulation of tissue growth.
Life Sci.
1986; 38( 25):
2355-62.
Stevens, K. E. Leslie, F. M. Evans, C. J. Barchas, J. D. Belluzzi, J. D. Stein, L. Intraventricular administration of BAM-18: antinociceptive and locomotor activity in the rat.
NIDA Res Monogr.
1986; 75(number):
446-9.
Kaldany, R. R. Campanelli, J. T. Makk, G. Evans, C. J. Scheller, R. H. Proteolytic processing of a peptide precursor in Aplysia neuron R14.
J Biol Chem.
1986; 261( 13):
5751-7.
Hurlbut, D. E. Evans, C. J. Barchas, J. D. Leslie, F. M. The pharmacological profile of BAM 18.
NIDA Res Monogr.
1986; 75(number):
81-4.
Evans, C. J. Erdelyi, E. Hunter, J. Barchas, J. D. Co-localization and characterization of immunoreactive peptides derived from two opioid precursors in guinea pig adrenal glands.
J Neurosci.
1985; 5( 12):
3423-7.
Lorenz, R. G. Evans, C. J. Barchas, J. D. Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary.
Life Sci.
1985; 37( 16):
1523-8.
Evans, C. J. Barchas, J. D. Esch, F. S. Bohlen, P. Weber, E. Isolation and characterization of an endogenous C-terminal fragment of the alpha-neo-endorphin/dynorphin precursor from bovine caudate nucleus.
J Neurosci.
1985; 5( 7):
1803-7.
Roth, K. A. Makk, G. Beck, O. Faull, K. Tatemoto, K. Evans, C. J. Barchas, J. D. Isolation and characterization of substance P, substance P 5-11, and substance K from two metastatic ileal carcinoids.
Regul Pept.
1985; 12( 3):
185-99.
Wallace, E. F. Weber, E. Barchas, J. D. Evans, C. J. A putative processing enzyme from Aplysia that cleaves dynorphin A at the single arginine residue.
Biochem Biophys Res Commun.
1984; 119( 1):
415-22.
Bostwick, D. G. Roth, K. A. Evans, C. J. Barchas, J. D. Bensch, K. G. Gastrin-releasing peptide, a mammalian analog of bombesin, is present in human neuroendocrine lung tumors.
Am J Pathol.
1984; 117( 2):
195-200.
Roth, K. A. Evans, C. J. Weber, E. Barchas, J. D. Bostwick, D. G. Bensch, K. G. Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor.
Cancer Res.
1983; 43( 11):
5411-5.
Evans, C. J. Erdelyi, E. Weber, E. Barchas, J. D. Identification of pro-opiomelanocortin-derived peptides in the human adrenal medulla.
Science.
1983; 221( 4614):
957-60.
Roth, K. A. Evans, C. J. Lorenz, R. G. Weber, E. Barchas, J. D. Chang, J. K. Identification of gastrin releasing peptide-related substances in guinea pig and rat brain.
Biochem Biophys Res Commun.
1983; 112( 2):
528-36.
Boarder, M. R. Weber, E. Evans, C. J. Erdelyi, E. Barchas, J. Measurement of total opioid peptides in rat brain and pituitary by radioimmunoassay directed at the alpha-N-acetyl derivative.
J Neurochem.
1983; 40( 6):
1517-22.
Weber, E. Esch, F. S. Bohlen, P. Paterson, S. Corbett, A. D. McKnight, A. T. Kosterlitz, H. W. Barchas, J. D. Evans, C. J. Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain.
Proc Natl Acad Sci U S A.
1983; 80( 23):
7362-6.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D. Antibodies specific for alpha-N-acetyl-beta-endorphins: radioimmunoassays and detection of acetylated beta-endorphins in pituitary extracts.
J Neurochem.
1982; 38( 2):
436-47.
Mues, G. Fuchs, I. Wei, E. T. Weber, E. Evans, C. J. Barchas, J. D. Chang, J. K. Blood pressure elevation in rats by peripheral administration of Tyr-Gly-Gly-Phe-Met-Arg-Phe and the invertebrate neuropeptide, Phe-Met-Arg-Phe-NH2.
Life Sci.
1982; 31( 23):
2555-61.
Weber, E. Evans, C. J. Chang, J. K. Barchas, J. D. Brain distributions of alpha-neo-endorphin and beta-neo-endorphin: evidence for regional processing differences.
Biochem Biophys Res Commun.
1982; 108( 1):
81-8.
Weber, E. Evans, C. J. Barchas, J. D. Mapping of hypothalamic opioid peptide neurons by a novel immunohistochemical technique: relation to alpha-Neo-endorphin and vasopressin systems.
Adv Biochem Psychopharmacol.
1982; 33(number):
519-26.
Weber, E. Evans, C. J. Barchas, J. D. Predominance of the amino-terminal octapeptide fragment of dynorphin in rat brain regions.
Nature.
1982; 299( 5878):
77-9.
Evans, C. J. Lorenz, R. Weber, E. Barchas, J. D. Variants of alpha-melanocyte stimulating hormone in rat brain and pituitary evidence that acetylated alpha-MSH exists only in the intermediate lobe of pituitary.
Biochem Biophys Res Commun.
1982; 106( 3):
910-9.
Weber, E. Evans, C. J. Barchas, J. D. Acetylated and nonacetylated forms of beta-endorphin in rat brain and pituitary.
Biochem Biophys Res Commun.
1981; 103( 3):
982-9.
Weber, E. Truscott, R. J. Evans, C. Sullivan, S. Angwin, P. Barchas, J. D. Alpha-N-acetyl beta-endorphins in the pituitary: immunohistochemical localization using antibodies raised against dynorphin(1-13).
J Neurochem.
1981; 36( 6):
1977-85.
Evans, C. J. Weber, E. Barchas, J. D. Isolation and characterization of alpha-N-acetyl beta-endorphin(1-26) from the rat posterior/intermediate pituitary lobe.
Biochem Biophys Res Commun.
1981; 102( 3):
897-904.
Weber, E. Evans, C. J. Samuelsson, S. J. Barchas, J. D. Novel peptide neuronal system in rat brain and pituitary.
Science.
1981; 214( 4526):
1248-51.
Austen, B. M. Evans, C. J. Smyth, D. G. Susceptibility of neuroactive peptides to aminopeptidase digestion is related to molecular size.
Biochem Biophys Res Commun.
1979; 91( 4):
1211-7.
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