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Bio:
Dr. X. William Yang is an associate professor in the Department of Psychiatry & Biobehavioral Sciences at David Geffen School of Medicine at UCLA. He is also a member of the Center for Neurobehavioral Genetics at Semel Institute for Neuroscience & Human Behaviors, and a member of the Brain Research Institute at UCLA. He serves as a regular member at the NIH’s Cell Death in Neurodegeneration (CDIN) Study Section, a Scientific Advisory Board member of the Hereditary Disease Foundation, and a faculty member for Faculty 1000 Medicine’s Neurogenetics Section.
William grew up in Tianjin, China. He obtained a combined M.S. and B.S. degrees with summa cum laude from Molecular Biophysics & Biochemistry Department at Yale University in 1991. He received Ph.D. in Molecular Genetics and Neuroscience from Rockefeller University in 1998. During his PhD thesis research with Dr. Nathaniel Heintz, William co-invented(together with Nat Heintz and Peter Model) a novel mouse genetic technology using large pieces of DNA called Bacterial Artificial Chromosomes (BACs) to make genetically-engineered mice called transgenic mice. The BAC transgenic technology is now a widely-used tool to generate transgenic animals for analyses of gene expression and gene function, and for modeling human diseases.
After obtaining his PhD degree, William went on to complete his M.D. training from Weill Medical College of Cornell University in 2000, and his Medicine Internship at New York-Presbyterian Hospital in 2001. After a brief postdoctoral training with Nat Heintz at Rockefeller University, William joined UCLA as an Assistant Professor in Dept. of Psychiatry in 2002.
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Research Interest:
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Our laboratory is interested in applying advanced mouse molecular genetic approaches, complemented with cell biological and biochemical approaches, to study the following two questions: (1) what are the cellular and molecular mechanisms underlying late-onset neurodegeneration in Huntington’s disease (HD) and Parkinson’s disease (PD)? And (2) how does the mammalian basal ganglia (BG) neural circuit normally function, and how does dysfunction of this circuit lead to clinical manifestations of movement disorders, psychiatric disorders, and drug addictions? A unitary theme of the our research is to elucidate the fundamental mechanisms underlying the function, dysfunction, and degeneration of the mammalian basal ganglia (BG).
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To download the uploaded CV/Resume click below:
Curriculum Vitae
Publications:
Spampanato J, Gu X, Yang X W, Mody I Progressive synaptic pathology of motor cortical neurons in a BAC
transgenic mouse model of Huntington's disease..
Neuroscience.
2008; 157(3):
606-20.
Gray Michelle, Shirasaki Dyna I, Cepeda Carlos, André Véronique M, Wilburn Brian, Lu Xiao-Hong, Tao Jifang, Yamazaki Irene, Li Shi-Hua, Sun Yi E, Li Xiao-Jiang, Levine Michael S, Yang X William Full-length human mutant huntingtin with a stable polyglutamine repeat
can elicit progressive and selective neuropathogenesis in BACHD mice..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008; 28(24):
6182-95.
Lobo Mary Kay, Cui Yijun, Ostlund Sean B, Balleine Bernard W, Yang X William Genetic control of instrumental conditioning by striatopallidal
neuron-specific S1P receptor Gpr6..
Nature neuroscience.
2007; 10(11):
1395-7.
Gu Xiaofeng, André Véronique M, Cepeda Carlos, Li Shi-Hua, Li Xiao-Jiang, Levine Michael S, Yang X William Pathological cell-cell interactions are necessary for striatal
pathogenesis in a conditional mouse model of Huntington's disease..
Molecular neurodegeneration.
2007; 2(11):
8.
Yang Zhongan, Jiang Hong, Chachainasakul Thawinee, Gong Shiaoching, Yang Xiangdong William, Heintz Nathaniel, Lin Shuo Modified bacterial artificial chromosomes for zebrafish transgenesis..
Methods (San Diego, Calif.).
2006; 39(3):
183-8.
Lobo Mary Kay, Karsten Stanislav L, Gray Michelle, Geschwind Daniel H, Yang X William FACS-array profiling of striatal projection neuron subtypes in
juvenile and adult mouse brains..
Nature neuroscience.
2006; 9(3):
443-52.
Gu Xiaofeng, Li Chenjian, Wei Weizheng, Lo Victor, Gong Shiaoching, Li Shi-Hua, Iwasato Takuji, Itohara Shigeyoshi, Li Xiao-Jiang, Mody Istvan, Heintz Nathaniel, Yang X William Pathological cell-cell interactions elicited by a neuropathogenic form
of mutant Huntingtin contribute to cortical pathogenesis in HD mice..
Neuron.
2005; 46(3):
433-44.
Gong Shiaoching, Yang Xiangdong William, Li Chenjian, Heintz Nathaniel Highly efficient modification of bacterial artificial chromosomes
(BACs) using novel shuttle vectors containing the R6Kgamma origin of
replication..
Genome research.
2002; 12(12):
1992-8.
Yang X W, Wynder C, Doughty M L, Heintz N BAC-mediated gene-dosage analysis reveals a role for Zipro1
(Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin..
Nature genetics.
1999; 22(4):
327-35.
Yang X W, Model P, Heintz N Homologous recombination based modification in Escherichia coli and
germline transmission in transgenic mice of a bacterial artificial
chromosome..
Nature biotechnology.
1997; 15(9):
859-65.
Yang X W, Zhong R, Heintz N Granule cell specification in the developing mouse brain as defined by
expression of the zinc finger transcription factor RU49..
Development (Cambridge, England).
1996; 122(2):
555-66.
Baserga S J, Gilmore-Hebert M, Yang X W Distinct molecular signals for nuclear import of the nucleolar snRNA,
U3..
Genes & development.
1992; 6(6):
1120-30.
Baserga S J, Yang X D, Steitz J A Three pseudogenes for human U13 snRNA belong to class III..
Gene.
1991; 107(2):
347-8.
Baserga S J, Yang X D, Steitz J A An intact Box C sequence in the U3 snRNA is required for binding of
fibrillarin, the protein common to the major family of nucleolar
snRNPs..
The EMBO journal.
1991; 10(9):
2645-51.
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