Publications:
Schaffer, B.A.J., Bertram, L., Miller, B.L., Mullin, K., Weintraub, S., Johnson, N., Bigio, E.H., Mesulam, M., Wiedau-Pazos, M., Jackson, G.R., Cummings, J.L., Cantor, R.M., Levey, A.I., Tanzi, R.E., and Geschwind, D.H. Association of GSK-3beta with Alzheimer's disease and frontotemporal dementia.
Arch Neurol
;
in press.
Jackson, G.R. Guide to understanding Drosophila models of neurodegenerative disorders.
PLoS Biol
2008; 6:
0236-0239.
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Sang, T.-K., Chang, H.-Y., Lawless, G.M., Ratnaparkhi, A., Mee, L., Ackerson, L.C., Maidment, N.T., Krantz, D.E., and Jackson, G.R. A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.
J Neurosci
2007; 27:
981-992.
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Krantz, D.E., and Jackson, G.R. Model Organisms and Neurogenetics.
Neurogenetics of Psychiatric Disorders
2007; Sawa, A., and McInnis, M.G., eds.:
117-133.
Karsten, S.L., Sang, T.-K., Gehman, L.T., Chatterjee, S., Liu, J., Lawless, G..M., Sengupta, S., Berry, R.W., Pomakian, J., Oh, H.S., Schulz, C., Hui, K.-S., Wiedau-Pazos, M., Vinters, H.V., Binder, L.I., Geschwind, D.H., and Jackson, G.R. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.
Neuron
2006; 51:
549-560.
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The Huntington Study Group PHAROS Investigators At risk for Huntington disease: The PHAROS (Prospective Huntington At Risk Observational Study) cohort enrolled.
Arch. Neurol.
2006; 63:
991-996.
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Fogel, B., Wu, M., Kremen, S., Murthy, K., Jackson, G.R., and Vanek, Z. Creutzfeldt-Jakob disease presenting with alien limb sign.
Movement Disorders
2006;
21:1040-1042.
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Sengupta, S., Horowitz, P.M., Karsten, S.L., Jackson, George R., Geschwind, D.H., Fu, Y, Berry, R.W., and Binder, L.I. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro.
Biochemistry
2006; 45:
15111-15119.
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Jackson, G.R., Sang, T.-K., and Taylor, J.P.
Drosophila Models of Polyglutamine Disorders.
Genetic Instabilities and Neurological Diseases
2006; 2:
587-594.
Slepko, N., Bhattacharyya, A.M., Jackson, G.R., Steffan, J.S., Marsh, J.L., Thompson, L.M., and Wetzel R.
Normal repeat length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins..
Proc Natl Acad Sci USA
2006; 103:
14367-14372.
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Sang, T-K., and Jackson, G.R. Drosophila models of neurodegenerative disease.
NeuroRx
2005; 2:
438-446.
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Jackson, G.R., and Lang, A.E. Hyperkinetic Movement Disorders.
Textbook of Geriatric Neuropsychiatry
2000; 2:
531-558.
Jackson, G.R. Modeling Neurodegenerative Diseases in the Fruit Fly.
Molecular Mechanisms of Neurodegenerative Diseases.
2000;
373-406.
Pan, Z., Sampath, D., Jackson, G., Werrbach-Perez, K., and Perez-Polo, R. Nerve growth factor and oxidative stress in the nervous system.
Adv. Exp. Med. Biol..
1997; 429:
173-193.
Jackson, G.R., and Perez-Polo, J.R. Paradigms for study of neurotrophin effects in oxidant injury.
Methods in Neuroscience
1996; 30:
1-25.
Jackson, G.R., Werrbach-Perez, K., Pan, Z., Sampath, D., and Perez-Polo, J.R. Neurotrophin regulation of energy homeostasis in the central nervous system.
Developmental Neuroscience .
1994; 16(5-6):
285-290.
Taglialatela G., Angelucci, L., Ramacci, M.-T., Werrbach-Perez, K., Jackson, G.R., and Perez-Polo, J.R. Acetyl-L-carnitine stimulates the synthesis of nerve growth factor receptors in a rat pheochromocytoma cell line..
Biochem. Pharmacol. .
1992; 44:
577 585.
Werrbach-Perez, K., Jackson, G., Marchetti, D., Morgan, B., Thorpe, L., and Perez-Polo, J.R. Growth factor-mediated protection in aging CNS..
Progress in Brain Research .
1990; 86:
183-194.
Perez-Polo, J.R., Foreman, J., Jackson, G., Shan, D., Taglialatela, G., Thorpe, L.W., and Werrbach-Perez, K. Nerve growth factor and neuronal cell death.
Mol. Neurobiol.
1990; 4:
57-91.
Perez-Polo, J.R., Werrbach-Perez, K., Jackson, G., Beck, C., Marchetti, D., Morgan, B., Taglialatela, G., Ramacci, M.T., and Angelucci, L. Neuronotrophic factors in aged rat central nervous system.
Aging Brain and Dementia: New Trends in Diagnosis and Therapy
1990;
296-318.
Jackson, G.R., Werrbach-Perez, K., and Perez-Polo, J.R. Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. II. A conditioning lesion paradigm.
J. Neurosci. Res. .
1990; 25:
369-364.
Jackson, G.R., Morgan, B., Werrbach-Perez, K., and Perez-Polo, J.R. Model for the study of conditioning lesions in the pathophysiology of the nervous system..
Advances in Myochemistry
1989; 2:
103-115.
Ratnaparkhi, A., Lawless, G.M., Schweizer, F.E., Golshani, P., and Jackson, G.R. A Drosophila model of ALS: Human ALS-associated mutation in VAP33A identifies a dominant negative mechanism.
PLoS One
2008; 3:
e2334.
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Mee, L., Honkala, H., Kopra, O., Vesa, J., Finnila, S., Visapaa, I., Sang, T.-K., Jackson, G.R., Salonen, R., Kestila, M., and Peltonen, L. Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1.
Human Molecular Genetics .
2005; 14(11):
1475-1488.
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Hogarth, P., Kayson, E., Kieburtz, K., Marder, K., Oakes, D., Rosas, D., Shoulson, I., Wexler, N.S., Young, A.B., and Zhao, H. Interrater agreement in the assessment of motor manifestations of Huntington's disease.
Movement Disorders.
2005; 20(3):
293-297.
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Sang, T.K., Li, C., Liu, W., Rodriguez, A., Abrams, J.M., Zipursky, S.L., and Jackson, G.R. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis.
Human Molecular Genetics.
2005; 14(3):
357-372.
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Jackson, G.R., Wiedau-Pazos, M., Sang, T.-K., Wagle, N., Brown, C.A., Massachi, S., and Geschwind, D.H. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila.
Neuron.
2002; 34(4):
509-519.
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Steffan, J.S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B.L., Kazantsev, A., Schmidt, E., Zhu, Y.Z., Greenwald, M., Kurokawa, R., Housman, D.E., Jackson, G.R., Marsh, J.L., and Thompson, L.M. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.
Nature.
2001; 413(6857):
739-743.
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Jackson, G.R., Salecker, I. Dong, X., Yao, X., Arnheim, N., Faber, P.W., MacDonald, M.E. and Zipursky, S.L. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.
Neuron .
1998; 21(3):
633-642.
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Sampath, D., Jackson, G.R., Werrbach-Perez, K., and Perez-Polo, J.R. Effects of nerve growth factor on glutathione peroxidase and catalase in PC12 cells.
Journal of Neurochemistry .
1994; 62(6):
2476-2479.
Jackson, G.R., Sampath, D., Werrbach-Perez, K., and Perez-Polo, J.R. Effects of nerve growth factor on catalase and glutathione peroxidase in a hydrogen peroxide-resistant pheochromocytoma subclone.
Brain Research .
1994; 634(1):
69-76.
Jackson, G.R., Werrbach-Perez, K., Ezell, E.L., Post, J.F., and Perez-Polo, J.R. Nerve growth factor effects on pyridine nucleotides after oxidant injury of rat pheochromocytoma cells.
Brain Research.
1992; 592(1-2):
239-248.
Foreman, P.J., Taglialatela, G., Jackson, G.R., and Perez-Polo, J.R. Dexamethasone blocks nerve growth factor induction of nerve growth factor receptor mRNA in PC12 cells.
Journal of Neuroscience Research .
1992; 31(1):
52-57.
Taglialatela, G., Angelucci, L., Ramacci, M.T., Werrbach-Perez, K., Jackson, G.R., and Perez-Polo, J.R. Acetyl-L-carnitine enhances the response of PC12 cells to nerve growth factor.
Developmental Brain Research .
1991; 59(2):
221-230.
Jackson, G.R., Apffel, L., Werrbach-Perez, K., and Perez-Polo, J.R. Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance.
Journal of neuroscience Research .
1990; 25(3):
360-368.
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