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Bio:
Gary Small, MD, is Professor of Psychiatry and Biobehavioral Sciences and Parlow-Solomon Professor on Aging at the David Geffen School of Medicine at UCLA, where he is also Founding Director of the UCLA Memory Clinic and Director of the UCLA Center on Aging.
Dr. Small was a phi beta kappa, summa cum laude graduate of UCLA and earned his medical degree (alpha omega alpha) at the University of Southern California. After an internal medicine internship at Children’s Hospital and Adult Medical Center in San Francisco, he completed a psychiatry residency at Massachusetts General Hospital and a clinical fellowship at Harvard Medical School. Dr. Small then completed a geriatric psychiatry fellowship at UCLA.
He has authored more than 400 scientific publications, as well as the international bestseller, "The Memory Bible." Dr Small is the recipient of many awards and honors, including the Jack Weinberg Award from the American Psychiatric Association and the Senior Investigator Award from the American Association for Geriatric Psychiatry. In 2002, Scientific American magazine named Dr. Small one of the world's top 50 innovators in science and technology.
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Research Interest:
Research Interests for Dr. Gary Small
Dr. Small’s research focuses on early detection and prevention of Alzheimer’s disease. These studies are driven by scientific evidence that supports the principle that protecting the brain from damage is a more feasible strategy than repairing already damaged neurons. Thus, identifying persons with mild cognitive complaints who are at risk for Alzheimer’s disease will allow testing of anti-dementia prevention treatments in high-risk persons before extensive brain damage develops. To this end, Small leads a group of investigators that is studying and developing genetic and brain imaging tools for testing prevention treatments for people with age-related memory loss.
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To download the uploaded CV/Resume click below:
Curriculum Vitae
Publications:
Small GW, Erkinjuntti T, Kurz A, Lilienfeld S Galantamine in the treatment of cognitive decline in patients with vascular dementia or Alzheimer's disease with cerebrovascular disease.
CNS Drugs
2003;
17:905-914.
Agdeppa ED, Kepe V, Petric A, Satyamurthy N, Liu J, Huang S-C, Small GW, Cole GM, Barrio JR In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile.
Neuroscience
2003;
117:723-730.
Braskie Michael E, Klunder Michael E, Hayashi Michael E, Protas Michael E, Kepe Michael E, Miller Michael E, Huang Michael E, Barrio Michael E, Ercoli Michael E, Siddarth Michael E, Satyamurthy Michael E, Liu Michael E, Toga Michael E, Bookheimer Michael E, Small Michael E, Thompson Michael E Plaque and tangle imaging and cognition in normal aging and
Alzheimer's disease..
Neurobiology of aging.
2008; 16(12):
.
Rasgon Natalie L, Kenna Heather A, Geist Cheri, Small Gary, Silverman Daniel Cerebral metabolic patterns in untreated postmenopausal women with
major depressive disorder..
Psychiatry research.
2008; 164(1):
77-80.
Braskie Gary W, Small Gary W, Bookheimer Gary W Vascular health risks and fMRI activation during a memory task in
older adults..
Neurobiology of aging.
2008; 62(10):
.
Silverman Daniel H S, Mosconi Lisa, Ercoli Linda, Chen Wei, Small Gary W Positron emission tomography scans obtained for the evaluation of
cognitive dysfunction..
Seminars in nuclear medicine.
2008; 38(4):
251-61.
Kumar Anand, Ajilore Olusola, Kepe Vladimir, Barrio Jorge R, Small Gary Mood, cognition and in vivo protein imaging: the emerging nexus in
clinical neuroscience..
International journal of geriatric psychiatry.
2008; 23(6):
555-63.
Kenna Gary W, Rasgon Gary W, Geist Gary W, Small Gary W, Silverman Gary W Thalamo-Basal Ganglia Connectivity in Postmenopausal Women Receiving
Estrogen Therapy..
Neurochemical research.
2008; 38(4):
.
Small Gary W, Bookheimer Susan Y, Thompson Paul M, Cole Greg M, Huang S-C, Kepe Vladimir, Barrio Jorge R Current and future uses of neuroimaging for cognitively impaired
patients..
Lancet neurology.
2008; 7(2):
161-72.
Small Gary, Dubois Bruno A review of compliance to treatment in Alzheimer's disease: potential
benefits of a transdermal patch..
Current medical research and opinion.
2007; 23(11):
2705-13.
Cummings Jeffrey, Lefèvre Gilbert, Small Gary, Appel-Dingemanse Silke Pharmacokinetic rationale for the rivastigmine patch..
Neurology.
2007; 69(4 Suppl 1):
S10-3.
Small Gary W, Kepe Vladimir, Ercoli Linda M, Siddarth Prabha, Bookheimer Susan Y, Miller Karen J, Lavretsky Helen, Burggren Alison C, Cole Greg M, Vinters Harry V, Thompson Paul M, Huang S-C, Satyamurthy N, Phelps Michael E, Barrio Jorge R PET of brain amyloid and tau in mild cognitive impairment..
The New England journal of medicine.
2006; 355(25):
2652-63.
Small Gary W, Kepe Vladimir, Barrio Jorge R Seeing is believing: neuroimaging adds to our understanding of
cerebral pathology..
Current opinion in psychiatry.
2006; 19(6):
564-9.
Ercoli Linda, Siddarth Prabha, Huang Sung-Cheng, Miller Karen, Bookheimer Susan Y, Wright Benjamin C, Phelps Michael E, Small Gary Perceived loss of memory ability and cerebral metabolic decline in
persons with the apolipoprotein E-IV genetic risk for Alzheimer
disease..
Archives of general psychiatry.
2006; 63(4):
442-8.
Kepe Vladimir, Barrio Jorge R, Huang Sung-Cheng, Ercoli Linda, Siddarth Prabha, Shoghi-Jadid Kooresh, Cole Gregory M, Satyamurthy Nagichettiar, Cummings Jeffrey L, Small Gary W, Phelps Michael E Serotonin 1A receptors in the living brain of Alzheimer's disease
patients..
Proceedings of the National Academy of Sciences of the United States of America.
2006; 103(3):
702-7.
Kepe Vladimir, Huang Sung-Cheng, Small Gary W, Satyamurthy Nagichettiar, Barrio Jorge R Visualizing pathology deposits in the living brain of patients with
Alzheimer's disease..
Methods in enzymology.
2006; 412(3):
144-60.
Shoghi-Jadid Kooresh, Barrio Jorge R, Kepe Vladimir, Wu Hsiao-Ming, Small Gary W, Phelps Michael E, Huang Sung-Cheng Imaging beta-amyloid fibrils in Alzheimer's disease: a critical
analysis through simulation of amyloid fibril polymerization..
Nuclear medicine and biology.
2005; 32(4):
337-51.
Farlow Martin R, Small Gary W, Quarg Peter, Krause Andreas Efficacy of rivastigmine in Alzheimer's disease patients with rapid
disease progression: results of a meta-analysis..
Dementia and geriatric cognitive disorders.
2005; 20(2-3):
192-7.
Rasgon Natalie L, Silverman Daniel, Siddarth Prabha, Miller Karen, Ercoli Linda M, Elman Shana, Lavretsky Helen, Huang S-C, Phelps Michael E, Small Gary W Estrogen use and brain metabolic change in postmenopausal women..
Neurobiology of aging.
2005; 26(2):
229-35.
Miller Karen J, Rogers Steven A, Siddarth Prabha, Small Gary W Object naming and semantic fluency among individuals with genetic risk
for Alzheimer's disease..
International journal of geriatric psychiatry.
2005; 20(2):
128-36.
van der Walt Joelle M, Dementieva Yulia A, Martin Eden R, Scott William K, Nicodemus Kristin K, Kroner Charles C, Welsh-Bohmer Kathleen A, Saunders Ann M, Roses Allen D, Small Gary W, Schmechel Donald E, Murali Doraiswamy P, Gilbert John R, Haines Jonathan L, Vance Jeffery M, Pericak-Vance Margaret A Analysis of European mitochondrial haplogroups with Alzheimer disease
risk..
Neuroscience letters.
2004; 365(1):
28-32.
Small Gary W What does imaging add to the management of Alzheimer's disease?.
CNS spectrums.
2004; 9(7 Suppl 5):
20-3.
Cummings Jeffrey L, Silverman Dan, Small Gary, Phelps Michael The role of positron emission tomography in the diagnosis of
Alzheimer's disease..
Journal of the American Geriatrics Society.
2004; 52(3):
467-8; author reply 468-9.
Grossberg George T, Corey-Bloom Judy, Small Gary W, Tariot Pierre N Academic highlights: emerging therapeutic strategies in Alzheimer's
disease..
The Journal of clinical psychiatry.
2004; 65(2):
255-66; quiz 283-4.
Li Yi-Ju, Oliveira Sofia A, Xu Puting, Martin Eden R, Stenger Judith E, Scherzer Clemens R, Hauser Michael A, Scott William K, Small Gary W, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Pahwa Rajesh, Stern Mathew B, Hiner Bradley C, Jankovic Joseph, Goetz Christopher G, Mastaglia Frank, Middleton Lefkos T, Roses Allen D, Saunders Ann M, Schmechel Donald E, Gullans Steven R, Haines Jonathan L, Gilbert John R, Vance Jeffery M, Pericak-Vance Margaret A, Hulette Christine, Welsh-Bohmer Kathleen A Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer
disease and Parkinson disease..
Human molecular genetics.
2003; 12(24):
3259-67.
Silverman Daniel H S, Truong Co T, Kim Shanna K, Chang Carol Y, Chen Wei, Kowell Arthur P, Cummings Jeffrey L, Czernin Johannes, Small Gary W, Phelps Michael E Prognostic value of regional cerebral metabolism in patients
undergoing dementia evaluation: comparison to a quantifying parameter
of subsequent cognitive performance and to prognostic assessment
without PET..
Molecular genetics and metabolism.
2003; 80(3):
350-5.
Oliveira Sofia A, Martin Eden R, Scott William K, Nicodemus Kristin K, Small Gary W, Schmechel Donald E, Doraiswamy P Murali, Roses Allen D, Saunders Ann M, Gilbert John R, Haines Jonathan L, Vance Jeffery M, Pericak-Vance Margaret A The Q7R Saitohin gene polymorphism is not associated with Alzheimer
disease..
Neuroscience letters.
2003; 347(3):
143-6.
Erkinjuntti Timo, Kurz Alexander, Small Gary W, Bullock Roger, Lilienfeld Sean, Damaraju C V, Damaraju C V An open-label extension trial of galantamine in patients with probable
vascular dementia and mixed dementia..
Clinical therapeutics.
2003; 25(6):
1765-82.
Ercoli Linda M, Siddarth Prabha, Dunkin Jennifer J, Bramen Jennifer, Small Gary W MMSE items predict cognitive decline in persons with genetic risk for
Alzheimer's disease..
Journal of geriatric psychiatry and neurology.
2003; 16(2):
67-73.
Oliveira Sofia A, Scott William K, Martin Eden R, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Pahwa Rajesh, Stern Matthew B, Hiner Bradley C, Ondo William G, Allen Fred H, Scott Burton L, Goetz Christopher G, Small Gary W, Mastaglia Frank, Stajich Jeffrey M, Zhang Fengyu, Booze Michael W, Winn Michelle P, Middleton Lefkos T, Haines Jonathan L, Pericak-Vance Margaret A, Vance Jeffery M Parkin mutations and susceptibility alleles in late-onset Parkinson's
disease..
Annals of neurology.
2003; 53(5):
624-9.
van der Walt Joelle M, Nicodemus Kristin K, Martin Eden R, Scott William K, Nance Martha A, Watts Ray L, Hubble Jean P, Haines Jonathan L, Koller William C, Lyons Kelly, Pahwa Rajesh, Stern Matthew B, Colcher Amy, Hiner Bradley C, Jankovic Joseph, Ondo William G, Allen Fred H, Goetz Christopher G, Small Gary W, Mastaglia Frank, Stajich Jeffrey M, McLaurin Adam C, Middleton Lefkos T, Scott Burton L, Schmechel Donald E, Pericak-Vance Margaret A, Vance Jeffery M Mitochondrial polymorphisms significantly reduce the risk of Parkinson
disease..
American journal of human genetics.
2003; 72(4):
804-11.
Small Gary W, Agdeppa Eric D, Kepe Vladimir, Satyamurthy Nagichettiar, Huang Sung-Cheng, Barrio Jorge R In vivo brain imaging of tangle burden in humans..
Journal of molecular neuroscience : MN.
2002; 19(3):
323-7.
Small Gary W Use of neuroimaging to detect early brain changes in people at genetic
risk for Alzheimer's disease..
Advanced drug delivery reviews.
2002; 54(12):
1561-6.
Miller Karen J, Conney Janet C, Rasgon Natalie L, Fairbanks Lynn A, Small Gary W Mood symptoms and cognitive performance in women estrogen users and
nonusers and men..
Journal of the American Geriatrics Society.
2002; 50(11):
1826-30.
Silverman Daniel H S, Small Gary W Prompt identification of Alzheimer's disease with brain PET imaging of
a woman with multiple previous diagnoses of other neuropsychiatric
conditions..
The American journal of psychiatry.
2002; 159(9):
1482-8.
Mega Michael S, Small Gary W, Xu Mina L, Felix Jenaro, Manese Mario, Tran Nha P, Dailey Jason I, Ercoli Linda M, Bookheimer Susan Y, Toga Arthur W Hippocampal atrophy in persons with age-associated memory impairment:
volumetry within a common space..
Psychosomatic medicine.
2002; 64(3):
487-92.
Li Yi-Ju, Scott William K, Hedges Dale J, Zhang Fengyu, Gaskell P Craig, Nance Martha A, Watts Ray L, Hubble Jean P, Koller William C, Pahwa Rajesh, Stern Matthew B, Hiner Bradley C, Jankovic Joseph, Allen Fred A, Goetz Christopher G, Mastaglia Frank, Stajich Jeffrey M, Gibson Rachel A, Middleton Lefkos T, Saunders Ann M, Scott Burton L, Small Gary W, Nicodemus Kristin K, Reed Allison D, Schmechel Donald E, Welsh-Bohmer Kathleen A, Conneally P Michael, Roses Allen D, Gilbert John R, Vance Jeffery M, Haines Jonathan L, Pericak-Vance Margaret A Age at onset in two common neurodegenerative diseases is genetically
controlled..
American journal of human genetics.
2002; 70(4):
985-93.
Shoghi-Jadid Kooresh, Small Gary W, Agdeppa Eric D, Kepe Vladimir, Ercoli Linda M, Siddarth Prabha, Read Stephen, Satyamurthy Nagichettiar, Petric Andrej, Huang Sung-Cheng, Barrio Jorge R Localization of neurofibrillary tangles and beta-amyloid plaques in
the brains of living patients with Alzheimer disease..
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2002; 10(1):
24-35.
Bookheimer, SY Strojwas, MH Cohen, MS Saunders, AM Pericak-Vance, MA Mazziotta, JC Small, GW Patterns of brain activation in people at risk for Alzheimer's disease..
The New England Journal of Medicine. .
2000; 343(7):
450-6.
Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease..
Proceedings of the National Academy of Sciences of the United States of America. .
2000; 97(11):
6037-42.
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