Kenneth Dorshkind, Ph.D.

B and T Cell Development The development of B and T lymphocytes occurs in the bone marrow and thymus, respectively, in association with a supporting framework of stromal cells. One aim of our work is to characterize immature lymphoid progeny derived from pluripotential hematopoietic stem cells. A current focus of the laboratory is on the characterization of a B/macrophage progenitor that has recently been identified in adult bone marrow. The origin of these cells and the contribution of their progeny to the adult immune system is being assessed. Another major aim of the laboratory is to define the basis for thymic involution during aging and to develop protocols for rejuvenation of that organ. Multiple in vitro and in vivo systems have been developed to facilitate these studies. Students who enter the laboratory receive state of the art training in such techniques as cell culture, flow cytometry, and bone marrow transplantation. This background provides then the skills necessary to address issues in Hematopoiesis and Developmental Immunology.