Tomas Ganz, M.D., Ph.D.

Work Email Address:
tganz@mednet.ucla.edu

Work Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

37-055 - CHS
Campus -169017
CA
UNITED STATES

Work Phone Number:
(310) 825-6112
310-825-0133
310-825-749

Department / Division Affiliations:

Professor, Medicine, ACCESS Program: Dept. of Cellular & Molecular Pathology, Pathology and Laboratory Medicine

Director, ACCESS Program: Dept. of Cellular & Molecular Pathology

Member, Experimental Pathology, JCCC Hematopoietic Malignancies Program Area

ACCESS Affinity Group:

ACCESS Affinity - Molecular Basis of Disease

Bio:

Dr. Tomas Ganz received his Ph.D. in Applied Physics from Caltech in 1976 and M.D. from UCLA in 1978. After training in Internal Medicine and Pulmonary Medicine at UCLA, he joined the faculty in 1983. He has a joint appointment in the Departments of Medicine and Pathology and is involved in the graduate program in Molecular and Cellular Pathology.

Publications:

Sorensen OE, Thapa DR, Roupe KM, Valore EV, Sjobring U, Roberts AA, Schmidtchen A, Ganz T. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor.. J Clin Invest. 2006; 116(7): 1878-85.

Valore EV, Wiley DJ, Ganz T Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun 2006; 74(10): 5693-702.

Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006; 108(12): 3730-5.

Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 2006; 107(1): 328-33.

Ganz T Antimicrobial polypeptides. J Leukoc Biol. 2004; 75(1): 34-8.

Ganz T Hepcidin in iron metabolism. Curr Opin Hematol. 2004; 11(4): 251-4.

Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004; 36(1): 77-82.

Ganz T Defensins, antimicrobial peptides of innate immunity. Nature Reviews Immunology. 2003; 3: 710-720.

Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein (Plenary Article). Blood. 2003; 101: 2461-2463.

Ganz T Rings of Destruction.. Nature 2001; 412: 392-3.

Lehrer RI, Ganz T Antimicrobial peptides in mammalian and insect host defense.. Current Opinion in Immunology 1999; 11: 23-27.

Ganz T Defensins and host defense.. Science. 1999; 286: 420-421.

Lin L, Goldberg YP, Ganz T Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin.. Blood. . 2005; 106(8): 2884-9.

Linzmeier RM, Ganz T Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.. Genomics.. 2005; 86(4): 423-30.

Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.. Blood. . 2005; 106(6): 2196-9.

De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J The molecular basis of ferroportin-linked hemochromatosis.. Proceedings of the National Academy of Sciences of the United States of America. . 2005; 102(25): 8955-60.

Ganz T Hepcidin--a regulator of intestinal iron absorption and iron recycling by macrophages.. Best practice & research. Clinical haematology. . 2005; 18(2): 171-82.

Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia.. Blood. . 2005; 105(4): 1797-802.

Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C Hepcidin is decreased in TFR2 hemochromatosis.. Blood. . 2005; 105(4): 1803-6.

Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.. Science. . 2004; 306(5704): 2090-3.

Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.. The Journal of clinical investigation. . 2004; 113(9): 1271-6.

Ganz T Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.. Blood. . 2003; 102(3): 783-8.

Ganz T Microbiology: Gut defence. Nature. 2003; 422(6931): 478-9.

Ganz T Angiogenin: an antimicrobial ribonuclease.. Nature immunology. . 2003; 4(3): 213-4.

Cole AM, Ganz T, Liese AM, Burdick MD, Liu L, Strieter RM Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity.. Journal of immunology (Baltimore, Md. : 1950) . 2001; 167(2): 623-7.

Park CH, Valore EV, Waring AJ, Ganz T Hepcidin, a urinary antimicrobial peptide synthesized in the liver.. The Journal of biological chemistry. . 2001; 276(11): 7806-10.

Ganz T Paneth cells--guardians of the gut cell hatchery.. Nature immunology. . 2000; 1(2): 99-100.