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Linda Baum, M.D., Ph.D.




Work Email Address:
lbaum@mednet.ucla.edu

Mailing Address:
program address
BOX 951732, 4-730 MRL
Los Angeles, CA 90095
UNITED STATES

Work Address:
MRL 4730


Work Phone Number:
(310) 206-5985
(310) 206-6329


Department / Division Affiliations:
Professor, Pathology and Laboratory Medicine
ACCESS Affinity Group:
ACCESS Affinity - Immunology
Bio:

Linda Baum is an immunologist and pathologist who joined the UCLA Dept. of Pathology and Laboratory Medicine in 1989 as an Assistant Professor. Dr. Baum became a full Professor in 2002. Dr. Baum attended Stanford University, where she received a B.S. in Biology in 1979. She received her Ph.D., with Peter Cresswell in Immunology, and M.D. degrees from Duke University in 1986. Dr. Baum completed her residency in Clinical Pathology at UCLA in 1989, and is Board Certified in Clinical Pathology. She was a post-doctoral fellow in James Paulson's lab during her residency, where she investigated host effects on influenza virus tropism. As a faculty member at UCLA, Dr. Baum teaches in the Medical School and the Graduate School, and received the Excellence in Education Award. She has clinical responsibilities in the Division of Hematopathology, in the clinical hemostasis laboratory. Her current research focuses on the biochemistry of cell-cell interactions, especially those mediated by protein-saccharide interactions, in immune system and cancer models. She collaborates with UCLA investigators in the Nanoscience Institute, the Dept. of Chemistry and the Dept. of Microbiology, Immunology and Molecular Genetics. She is a member of several training programs, including the Immunopathology, Hematology/ Oncoloy, Tumor Cell Biology, Tumor Immunology, and Basic Immunology programs. She is also a member of the Medical Scientist Training Program Steering Committee, the Jonsson Comprehensive Cancer Center, and the Molecular Biology Institute.

Publications:


Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA Differential glycosylation of TH1, TH2 and TH17 effector cells selectively regulates susceptibility to cell death. Nature Immunology. 2007; 8: 825-834.
Belitsky JM, Nelson A, Hernandez JD, Baum LG, Stoddart JF Multivalent interactions between lectins and supramolecular complexes: galectin-1 and self-assembled pseudopolyrotaxanes. Chemistry and Biology. 2007; 14(10): 1140-1151.
Valenzuela H, Pace KE, Cabrera PV, White R, Porvari K, Kaija H, Vihko P, and Baum LG O-glycosylation regulates LNCaP prostate cancer cell susceptibility to apoptosis induced by galectin-1. Cancer Research. 2007; 67: 6155-62.
Hernandez JD, Klein J, Van Dyken SJ, Marth JD, Baum LG T cell activation results in microheterogeneous changes in glycosylation of CD45. International Immunology. 2007; 19(7): 847-56.
Perone MJ, Bertera S, Tawadrous ZS, Shufesky WJ, Piganelli JD, Baum LG, Trucco M, Morelli AE Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice. Journal of Immunology. 2006; 177: 5278-5289.
Hernandez JD, Nguyen JT, He J, Wang W, Ardman B, Green JM, Fukuda M, Baum LG Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. Journal of Immunology. 2006; 177: 5328-5336.
Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, Verhofstad N, Nakabeppu Y, Baum LG, Bakkers J, Mayo KH, Poirier F, Griffioen AW Galectin-1 is essential in tumor angiogenesis and is a target for anti-angiogenesis therapy.. Proceedings of the National Academy of Sciences. 2006; 103(43): 15975-15980.
He J and Baum LG Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T cell transendothelial migration. Laboratory Investigation. 2006; 86: 578-590.
Perone MJ, Larregine AT, Shufesky WJ, Papworth GD, Sullivan MLG, Zahorchak AF, Stolz DB, Baum LG, Watkins SC, Thomson AW, Morelli AT Transgenic galectin-1 induces maturation of dendritic cells that elicit contrasting responses on naive and activated T cells. Journal of Immunology. 2006; 176: 7207-7220.
Nelson A, Belitsky JM, Vidal S, Joiner CS, Baum LG, Stoddart JF A self-assembled multivalent pseudopolyrotaxane for binding galectin-1. Journal of the American Chemical Society . 2004; 126: 11914-22.
Hoyer KK, Pang M, Gui D, Shintaku IP, Kuwabara I, Liu FT, Said JW, Baum LG, Teitell MA An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas. The American Journal of Pathology . 2004; 164: 893-902.
Hahn HP, Pang M, He J, Hernandez JD, Yang RY, Li LY, Wang X, Liu FT, Baum LG Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death and Differentiation. 2004; 11: 1277-86.
Baum LG, Blackall DP, Arias-Magallano S, Nanigian D, Uh SY, Browne JM, Hoffmann D, Emmanouilides CE, Territo MC, Baldwin GC Amelioration of graft versus host disease by galectin-1. Clinical Immunology . 2003; 109: 295-307.
Amano M, Galvan M, He J, Baum LG The ST6Gal I sialyltransferase selectively modifies CD45 and negatively regulates galectin-1 induced CD45 clustering, phosphatase modulation and T cell death. Journal of Biological Chemistry. 2003; 278(9): 7469-7475.
Brewer CF, Miceli MC, Baum LG Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions. Current Opinion in Structural Biology . 2002; 12: 616-23.
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