Laboratory Address:
Lab Address Factor 8-240 UNITED STATES
Mailing Address:
Mailing Address Dept. of Pathology Mail Code 173216 10833 LeConte Avenue Los Angeles, CA 90095 UNITED STATES
Office Address:
Office Factor 8-240J Los Angeles, CA 90095 UNITED STATES
Lab Number:
x50618
Work Phone Number:
(310) 267-2799
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Assistant Professor,
Pathology and Laboratory Medicine,
Surgical Pathology,
Gastrointestinal & Liver Pathology
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Member,
ACCESS Program: Dept. of Cellular & Molecular Pathology
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ACCESS Affinity Group:
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| ACCESS Affinity - Molecular Basis of Disease |
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The biology of pancreatic cancer
Pancreatic cancer is a highly aggressive disease which accounts for over 30,000 deaths each year in the United States alone. As basic research continues to uncover an increasing number of genes with potentially important roles in pancreatic cancer, there is a need to translate these findings into clinically meaningful assays useful for the diagnosis and management of pancreatic cancer. My research focuses on refining the full range of molecular alterations associated with the initial development of pancreatic cancer, as well as its further progression to aggressive metastatic disease.
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Bio:
David Dawson is a cell and molecular biologist and practicing surgical pathologist who has served on the UCLA School of Medicine faculty since 2006 when he was appointed Assistant Professor in the Department of Pathology and Laboratory Medicine. Dr. Dawson earned his B.S. in Zoology at Duke University. He earned his M.D. and Ph.D. in Molecular Biology and Genetics at Northwestern University, where he worked on angiogenesis. Dr. Dawson completed his residency training in Anatomic Pathology and subspecialty fellowship in gastrointestinal pathology in the Department of Pathology at UCLA. From 2002 to 2006 he was a combined clinical instructor in surgical pathology and postdoctoral research fellow in the Department of Pathology at UCLA, where he worked on epigenetics and lymphomagenesis. Dr. Dawson's research currently involves basic and translational research on pancreatic tumorigenesis.
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Publications:
Dawson, D. W. Hong, J. S. Shen, R. R. French, S. W. Troke, J. J. Wu, Y. Z. Chen, S. S. Gui, D. Regelson, M. Marahrens, Y. Morse, H. C., 3rd Said, J. Plass, C. Teitell, M. A. Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.
Oncogene.
2007; 26( 29):
4243-52.
Frank, M. J. Dawson, D. W. Bensinger, S. J. Hong, J. S. Knosp, W. M. Xu, L. Balatoni, C. E. Allen, E. L. Shen, R. R. Bar-Sagi, D. Martin, G. R. Teitell, M. A. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas.
Blood.
2009; 113( 11):
2478-87.
Smiraglia, D. J. Kazhiyur-Mannar, R. Oakes, C. C. Wu, Y. Z. Liang, P. Ansari, T. Su, J. Rush, L. J. Smith, L. T. Yu, L. Liu, C. Dai, Z. Chen, S. S. Wang, S. H. Costello, J. Ioshikhes, I. Dawson, D. W. Hong, J. S. Teitell, M. A. Szafranek, A. Camoriano, M. Song, F. Elliott, R. Held, W. Trasler, J. M. Plass, C. Wenger, R. Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations.
BMC Genomics.
2007; 8(number):
446.
Tang, R. S. Weinberg, B. Dawson, D. W. Reber, H. Hines, O. J. Tomlinson, J. S. Chaudhari, V. Raman, S. Farrell, J. J. Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm.
Clin Gastroenterol Hepatol.
2008; 6( 7):
815-9; quiz 719.
Hasan, S. Satake, M. Dawson, D. W. Funahashi, H. Angst, E. Go, V. L. Reber, H. A. Hines, O. J. Eibl, G. Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers.
Pancreas.
2008; 37( 2):
121-7.
Thomas, R. M. Kim, J. Revelo-Penafiel, M. P. Angel, R. Dawson, D. W. Lowy, A. M. The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia.
Gut.
2008; 57( 11):
1555-60.
French, S. W. Dawson, D. W. Chen, H. W. Rainey, R. N. Sievers, S. A. Balatoni, C. E. Wong, L. Troke, J. J. Nguyen, M. T. Koehler, C. M. Teitell, M. A. The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity.
Cancer Lett.
2007; 248( 2):
198-210.
Funahashi, H. Satake, M. Dawson, D. Huynh, N. A. Reber, H. A. Hines, O. J. Eibl, G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.
Cancer Res.
2007; 67( 15):
7068-71.
Pelling, A. E. Dawson, D. W. Carreon, D. M. Christiansen, J. J. Shen, R. R. Teitell, M. A. Gimzewski, J. K. Distinct contributions of microtubule subtypes to cell membrane shape and stability.
Nanomedicine.
2007; 3( 1):
43-52.
French, S. W. Dawson, D. W. Miner, M. D. Doerr, J. R. Malone, C. S. Wall, R. Teitell, M. A. DNA methylation profiling: a new tool for evaluating hematologic malignancies.
Clin Immunol.
2002; 103( 3 Pt 1):
217-30.
Dawson, D. W. Volpert, O. V. Pearce, S. F. Schneider, A. J. Silverstein, R. L. Henkin, J. Bouck, N. P. Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat.
Mol Pharmacol.
1999; 55( 2):
332-8.
Dawson, D. W. Volpert, O. V. Gillis, P. Crawford, S. E. Xu, H. Benedict, W. Bouck, N. P. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis.
Science.
1999; 285( 5425):
245-8.
Dawson, D. W. Pearce, S. F. Zhong, R. Silverstein, R. L. Frazier, W. A. Bouck, N. P. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells.
J Cell Biol.
1997; 138( 3):
707-17.
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