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Steven Bensinger

Work Email Address:
sbensinger@mednet.ucla.edu

Mailing Address:
Mailing
Box 951735
Los Angeles, CA 90095
UNITED STATES

Office Address:
Office
36-120 CHS; 650 Charles E. Young Drive
Los Angeles, CA 90095

Lab Number:
310 206-1016
Office Phone Number:
310-825-9885

Academic Titles:

Assistant Professor of Pathology and Laboratory Medicine, Molecular & Medical Pharmacology

Bio:
Dr. Bensinger received his veterinary medical degree from the University of Pennsylvania School of Veterinary Medicine, and his Ph.D. from the University of Pennsylvania School of Medicine. He completed a thesis on regulatory T cell development and function in Dr. Laurence Turka�s lab. Dr. Bensinger then came to UCLA to complete a postdoctoral fellowship in the laboratory of Dr. Peter Tontonoz examining the impact of lipid metabolism on lymphocyte function and adaptive immunity.

Publications:

Hong Cynthia, Kidani Yoko, A-Gonzalez Noelia, Phung Tram, Ito Ayaka, Rong Xin, Ericson Katrin, Mikkola Hanna, Beaven Simon W, Miller Lloyd S, Shao Wen-Hai, Cohen Philip L, Castrillo Antonio, Tontonoz Peter, Bensinger Steven J Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.. The Journal of clinical investigation. 2012; 122(1): 337-47.

Wolkers Monika C, Bensinger Steven J, Green Douglas R, Schoenberger Stephen P, Janssen Edith M Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death.. Immunology letters. 2011; 139(1-2): 25-32.

Beaven Simon W, Wroblewski Kevin, Wang Jiaohong, Hong Cynthia, Bensinger Steven, Tsukamoto Hide, Tontonoz Peter Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease.. Gastroenterology. 2011; 140(3): 1052-62.

Ribas Vicent, Drew Brian G, Le Jamie A, Soleymani Teo, Daraei Pedram, Sitz Daniel, Mohammad Laila, Henstridge Darren C, Febbraio Mark A, Hewitt Sylvia C, Korach Kenneth S, Bensinger Steven J, Hevener Andrea L Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development.. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(39): 16457-62.

Bensinger, S. J. Tontonoz, P. A Nurr1 pathway for neuroprotection. Cell. 2009; 137(1): 26-8.

A. Gonzalez N Bensinger, S. J. Hong, C. Beceiro, S. Bradley, M. N. Zelcer, N. Deniz, J. Ramirez, C. Diaz, M. Gallardo, G. de Galarreta, C. R. Salazar, J. Lopez, F. Edwards, P. Parks, J. Andujar, M. Tontonoz, P. Castrillo, A. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 2009; 31(2): 245-58.

A-Gonzalez Noelia, Bensinger Steven J, Hong Cynthia, Beceiro Susana, Bradley Michelle N, Zelcer Noam, Deniz Jose, Ramirez Cristina, Díaz Mercedes, Gallardo German, de Galarreta Carlos Ruiz, Salazar Jon, Lopez Felix, Edwards Peter, Parks John, Andujar Miguel, Tontonoz Peter, Castrillo Antonio Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.. Immunity. 2009; 31(2): 245-58.

Frank, M. J. Dawson, D. W. Bensinger, S. J. Hong, J. S. Knosp, W. M. Xu, L. Balatoni, C. E. Allen, E. L. Shen, R. R. Bar-Sagi, D. Martin, G. R. Teitell, M. A. Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood. 2009; 113(11): 2478-87.

Hummasti, S. Hong, C. Bensinger, S. J. Tontonoz, P. HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation. J Lipid Res. 2008; 49(12): 2535-44.

Chao, L. C. Bensinger, S. J. Villanueva, C. J. Wroblewski, K. Tontonoz, P. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Mol Endocrinol. 2008; 22(12): 2596-608.

Bensinger, S. J. Tontonoz, P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature. 2008; 454(7203): 470-7.

Bensinger, S. J. Bradley, M. N. Joseph, S. B. Zelcer, N. Janssen, E. M. Hausner, M. A. Shih, R. Parks, J. S. Edwards, P. A. Jamieson, B. D. Tontonoz, P. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008; 134(1): 97-111.

Eck, S. C. Zhu, P. Pepper, M. Bensinger, S. J. Freedman, B. D. Laufer, T. M. Developmental alterations in thymocyte sensitivity are actively regulated by MHC class II expression in the thymic medulla. J Immunol. 2006; 176(4): 2229-37.

Saleh, M. Mathison, J. C. Wolinski, M. K. Bensinger, S. J. Fitzgerald, P. Droin, N. Ulevitch, R. J. Green, D. R. Nicholson, D. W. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature. 2006; 440(7087): 1064-8.

Walsh, P. T. Buckler, J. L. Zhang, J. Gelman, A. E. Dalton, N. M. Taylor, D. K. Bensinger, S. J. Hancock, W. W. Turka, L. A. PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs. J Clin Invest. 2006; 116(9): 2521-31.

Janssen, E. M. Droin, N. M. Lemmens, E. E. Pinkoski, M. J. Bensinger, S. J. Ehst, B. D. Griffith, T. S. Green, D. R. Schoenberger, S. P. CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death. Nature. 2005; 434(7029): 88-93.

Bensinger, S. J. Walsh, P. T. Zhang, J. Carroll, M. Parsons, R. Rathmell, J. C. Thompson, C. B. Burchill, M. A. Farrar, M. A. Turka, L. A. Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. J Immunol. 2004; 172(9): 5287-96.

Wu, Z. Bensinger, S. J. Zhang, J. Chen, C. Yuan, X. Huang, X. Markmann, J. F. Kassaee, A. Rosengard, B. R. Hancock, W. W. Sayegh, M. H. Turka, L. A. Homeostatic proliferation is a barrier to transplantation tolerance. Nat Med. 2004; 10(1): 87-92.

Biju, M. P. Neumann, A. K. Bensinger, S. J. Johnson, R. S. Turka, L. A. Haase, V. H. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol Cell Biol. 2004; 24(20): 9038-47.

Burchill, M. A. Goetz, C. A. Prlic, M. O'Neil, J. J. Harmon, I. R. Bensinger, S. J. Turka, L. A. Brennan, P. Jameson, S. C. Farrar, M. A. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003; 171(11): 5853-64.

Adler, S. H. Bensinger, S. J. Turka, L. A. Stemming the tide of rejection. Nat Med. 2002; 8(2): 107-8.

Bensinger, S. J. Bandeira, A. Jordan, M. S. Caton, A. J. Laufer, T. M. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med. 2001; 194(4): 427-38.

Wekerle, T. Kurtz, J. Sayegh, M. Ito, H. Wells, A. Bensinger, S. Shaffer, J. Turka, L. Sykes, M. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol. 2001; 166(4): 2311-6.

Schiaffella, E. Fuschiotti, P. Bensinger, S. J. Mage, R. G. High RAD51 mRNA levels in young rabbit appendix. A role in B-cell gene conversion?. Immunogenetics. 1998; 48(2): 108-15.

Callahan, H. L. Portal, I. F. Bensinger, S. J. Grogl, M. Leishmania spp: temperature sensitivity of promastigotes in vitro as a model for tropism in vivo. Exp Parasitol. 1996; 84(3): 400-9.