UCLA Healthcare


Christopher Denny, M.D.



Work Email Address:
cdenny@mednet.ucla.edu

Laboratory Address:
Lab Address
700 Westwood Blvd
Los Angeles, CA 90095
UNITED STATES

Office Address:
Office
10-240
CAMPUS - 175217
CA
UNITED STATES

Work Phone Number:
(310) 825-0704





Department / Division Affiliations
Co-Director, Gene Expression Core Shared Resource
Professor, Pediatrics
Member, ACCESS Program: MBI IDP, JCCC Signal Transduction and Therapeutics Program Area

ACCESS Affinity Group:

ACCESS Affinity - Tumor Cell Biology & Signal Transduction

Bio:

rock climbing biking

Publications:

Potikyan Gary, France Kelly A, Carlson Marc R J, Dong Jun, Nelson Stanley F, Denny Christopher T Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors.. Laboratory investigation; a journal of technical methods and pathology. 2008; 88(12): 1291-302.
Potikyan Gary, Savene Rupert O V, Gaulden Julie M, France Kelly A, Zhou Zhichao, Kleinerman Eugenie S, Lessnick Stephen L, Denny Christopher T EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.. Cancer research. 2007; 67(14): 6675-84.
Ng King Pan, Potikyan Gary, Savene Rupert O V, Denny Christopher T, Uversky Vladimir N, Lee Kevin A W Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins.. Proc. Natl. Acad. Sci. U.S.A.. 2007; 104(2): 479-84.
Kim Sungeun, Denny Christopher T, Wisdom Ron Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins.. Molecular and cellular biology. 2006; 26(7): 2467-78.
Davis Ian J, Kim Jessica J, Ozsolak Fatih, Widlund Hans R, Rozenblatt-Rosen Orit, Granter Scott R, Du Jinyan, Fletcher Jonathan A, Denny Christopher T, Lessnick Stephen L, Linehan W Marston, Kung Andrew L, Fisher David E Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.. Cancer cell. 2006; 9(6): 473-84.
Deneen Benjamin, Hamidi Habib, Denny Christopher T Functional analysis of the EWS/ETS target gene uridine phosphorylase.. Cancer research. 2003; 63(14): 4268-74.
Deneen Benjamin, Welford Scott M, Ho Thu, Hernandez Felicia, Kurland Irwin, Denny Christopher T PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins.. Molecular and cellular biology. 2003; 23(11): 3897-908.
Maris John M, Denny Christopher T Focus on embryonal malignancies.. Cancer cell. 2002; 2(6): 447-50.
Deneen B, Denny CT Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation.. Oncogene. . 2001; 20(46): 6731-41.
Arvand A, Welford S, Teitell MA, Denny CT The C-terminal domain of FLI-1 is necessary for full tumorigenic potential of the EWS/FLI1.. Cancer Research 2001; 61: 5311-17.
Welford SM, Gregg J, Chen E, Garrison D, Sorensen PH, Denny CT, Nelson SF Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization.. Nucleic acids research. . 1998; 26(12): 3059-65.
May WA, Arvand A, Thompson AD, Braun BS, Wright M, Denny CT EWS/FLI1-induced Manic Fringe renders NIH 3T3 cells tumorigenic.. Nature Genetics 1997; 17: 495-498.
UCLA Health Sciences  •  UCLA  •  Terms & Conditions  •  Privacy Practices  •  Disability Resources  •  ©UC Regents
Mattel Children's Hospital 
 UCLA Healthcare