Katrina Dipple, M.D., Ph.D.
Mailing Address:
Research Lab 695 Charles E. Young Drive South Los Angeles, CA 90095 UNITED STATES
Work Address:
Office Gonda 5506B UNITED STATES
Work Phone Number:
310-206-6581
310-825-1997
310-825-5904
310-825-7967
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ACCESS Affinity Group:
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| ACCESS Affinity - Genetics & Genomics |
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Bio:
Katrina M. Dipple, MD, PhD has always been interested in biochemistry and medicine. She has a BS in Biochemistry from Indiana University in Bloomington. During her undergraduate education she became interested in genetics and decided to go to graduate school. Dr. Dipple did a combined MD/PhD degree at Indiana University School of Medicine. Her PhD is in biochemistry and molecular biology. After finishing graduate school, she came to UCLA for a pediatric residency and postdoctoral fellowship in Genetics. Her career has focused on combining basic research and clinical work. Since joining the faculty, her work has focused on understanding the complexity of genetic disorders including the role of fat metabolism in type 2 diabetes mellitus.
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Zhang, Y. H. Huang, B. L. Jialal, I. Northrup, H. McCabe, E. R. Dipple, K. M. Asymptomatic isolated human glycerol kinase deficiency associated with splice-site mutations and nonsense-mediated decay of mutant RNA.
Pediatr Res.
2006; 59(4 Pt 1):
590-2.
Crombez, E. A. Dipple, K. M. Schimmenti, L. A. Rao, N. Duplication of the Down syndrome critical region does not predict facial phenotype in a baby with a ring chromosome 21.
Clin Dysmorphol.
2005; 14(4):
183-7.
Ohira, R.H., Dipple, K.M., Zhang, Y.-H., and McCabe, E.R.B. Human and murine glycerol kinase: Influence of exon 18 alternative splicing on function. Biochem. Biophys..
Research Comm
2005; 331:
239-246.
Sriram, G. Martinez, J. A. McCabe, E. R. Liao, J. C. Dipple, K. M. Single-gene disorders: what role could moonlighting enzymes play?.
Am J Hum Genet.
2005; 76(6):
911-24.
Zhang, Y. H. Huang, B. L. Niakan, K. K. McCabe, L. L. McCabe, E. R. Dipple, K. M. IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1.
Hum Mutat.
2004; 24(3):
273.
Stepanian, S. V. Huyn, S. T. McCabe, E. R. Dipple, K. M. Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation.
Mol Genet Metab.
2003; 80(4):
412-8.
Cederbaum, S. D. Koo-McCoy, S. Tein, I. Hsu, B. Y. Ganguly, A. Vilain, E. Dipple, K. Cvitanovic-Sojat, L. Stanley, C. Carnitine membrane transporter deficiency: a long-term follow up and OCTN2 mutation in the first documented case of primary carnitine deficiency.
Mol Genet Metab.
2002; 77(3):
195-201.
Ohira, R. Zhang, Y. H. Guo, W. Dipple, K. Shih, S. L. Doerr, J. Huang, B. L. Fu, L. J. Abu-Khalil, A. Geschwind, D. McCabe, E. R. Human ARX gene: genomic characterization and expression.
Mol Genet Metab.
2002; 77(1-2):
179-88.
Dipple, K. M. Phelan, J. K. McCabe, E. R. Consequences of complexity within biological networks: robustness and health, or vulnerability and disease.
Mol Genet Metab.
2001; 74(1-2):
45-50.
Dipple, K.M., McCabe, E.R.B. Consequences of complexity within metabolic networks: Robustness and health, or vulnerability and disease..
Mol. Genet. Metab.
2001; 74:
45-50.
Dipple, K. M. Zhang, Y. H. Huang, B. L. McCabe, L. L. Dallongeville, J. Inokuchi, T. Kimura, M. Marx, H. J. Roederer, G. O. Shih, V. Yamaguchi, S. Yoshida, I. McCabe, E. R. Glycerol kinase deficiency: evidence for complexity in a single gene disorder.
Hum Genet.
2001; 109(1):
55-62.
Zhang, Y. Dipple, K. M. Vilain, E. Huang, B. L. Finlayson, G. Therrell, B. L. Worley, K. Deininger, P. McCabe, E. R. AluY insertion (IVS4-52ins316alu) in the glycerol kinase gene from an individual with benign glycerol kinase deficiency.
Hum Mutat.
2000; 15(4):
316-23.
Zhang, Y Dipple, KM Vilain, E Huang, BL Finlayson, G Therrell, BL Worley, K Deininger, P McCabe, ER AluY insertion (IVS4-52ins316alu) in the glycerol kinase gene from an individual with benign glycerol kinase deficiency..
Human mutation. .
2000; 15(4):
316-23.
Dipple, K. M. McCabe, E. R. Modifier genes convert "simple" Mendelian disorders to complex traits.
Mol Genet Metab.
2000; 71(1-2):
43-50.
Dipple, K. M. McCabe, E. R. Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics.
Am J Hum Genet.
2000; 66(6):
1729-35.
Pinaire, J. Chou, W. Y. Stewart, M. Dipple, K. Crabb, D. Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1.
Adv Exp Med Biol.
1999; 463:
115-21.
Dipple, K. M. The resident's column.
Pediatr Ann.
1997; 26(9):
523-4.
Dipple, K. M. Stewart, M. J. Crabb, D. W. Tissue-specific expression and preliminary functional analysis of the 5' flanking regions of the human mitochondrial aldehyde dehydrogenase (ALDH2) gene.
Adv Exp Med Biol.
1995; 372:
123-30.
Crabb, D. W. Dipple, K. M. Thomasson, H. R. Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes.
J Lab Clin Med.
1993; 122(3):
234-40.
Dipple, K. M. Qulali, M. Ross, R. A. Crabb, D. W. Effects of thyroxine on the expression of alcohol dehydrogenase in rat liver and kidney.
Hepatology.
1993; 17(4):
701-6.
Qulali, M. Dipple, K. M. Crabb, D. W. Modulation of hepatic and renal alcohol dehydrogenase activity and mRNA by steroid hormones in vivo.
Adv Exp Med Biol.
1993; 328:
581-9.
Crabb, D. W. Qulali, M. Dipple, K. M. Endocrine regulation and methylation patterns of rat class I alcohol dehydrogenase in liver and kidney.
Adv Exp Med Biol.
1991; 284:
277-84.
Crabb, D. W. Stein, P. M. Dipple, K. M. Hittle, J. B. Sidhu, R. Qulali, M. Zhang, K. Edenberg, H. J. Structure and expression of the rat class I alcohol dehydrogenase gene.
Genomics.
1989; 5(4):
906-14.
MacLennan, N. K. Rahib, L. Shin, C. Fang, Z. Horvath, S. Dean, J. Liao, J. C. McCabe, E. R. Dipple, K. M. Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity.
Hum Mol Genet.
2006; 15(3):
405-15.
MacLennan NK, Rahib L, Shin C, Fang Z, Horvath S, Dean J, Liao JC, McCabe ER, Dipple KM. Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity.
Hum Mol Genet..
2006; 15(3):
405-15.
MacLennan, N. K. Rahib, L. Shin, C. Fang, Z. Horvath, S. Dean, J. Liao, J. C. McCabe, E. R. Dipple, K. M. Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity.
Hum Mol Genet.
2006; 15(3):
405-15.
Kuwada, N. Nagano, K. MacLennan, N. Havens, J. Kumar, M. Dipple, K. M. McCabe, E. R. Gene therapy for murine glycerol kinase deficiency: importance of murine ortholog.
Biochem Biophys Res Commun.
2005; 335(1):
247-55.
Sriram, G Martinez, JA McCabe, ER Liao, JC Dipple, KM Single-gene disorders: what role could moonlighting enzymes play?.
American journal of human genetics. .
2005; 76(6):
911-24.
Ohira, R. H. Dipple, K. M. Zhang, Y. H. McCabe, E. R. Human and murine glycerol kinase: influence of exon 18 alternative splicing on function.
Biochem Biophys Res Commun.
2005; 331(1):
239-46.
Zhang, YH Huang, BL Niakan, KK McCabe, LL McCabe, ER Dipple, KM IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1..
Human mutation. .
2004; 24(3):
273.
Stepanian, SV Huyn, ST McCabe, ER Dipple, KM Characterization of the human glycerol kinase promoter: identification of a functional HNF-4alpha binding site and evidence for transcriptional activation..
Molecular genetics and metabolism. .
2003; 80(4):
412-8.
Dipple, KM Zhang, YH Huang, BL McCabe, LL Dallongeville, J Inokuchi, T Kimura, M Marx, HJ Roederer, GO Shih, V Yamaguchi, S Yoshida, I McCabe, ER Glycerol kinase deficiency: evidence for complexity in a single gene disorder..
Human genetics. .
2001; 109(1):
55-62.
Stewart, M. J. Dipple, K. M. Estonius, M. Nakshatri, H. Everett, L. M. Crabb, D. W. Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4.
Biochim Biophys Acta.
1998; 1399(2-3):
181-6.
Stewart, M. J. Dipple, K. M. Stewart, T. R. Crabb, D. W. The role of nuclear factor NF-Y/CP1 in the transcriptional regulation of the human aldehyde dehydrogenase 2-encoding gene.
Gene.
1996; 173(2):
155-61.
Stewart, M. J. Malek, K. Xiao, Q. Dipple, K. M. Crabb, D. W. The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.
Biochem Biophys Res Commun.
1995; 211(1):
144-51.
Dipple, K. M. Crabb, D. W. The mitochondrial aldehyde dehydrogenase gene resides in an HTF island but is expressed in a tissue-specific manner.
Biochem Biophys Res Commun.
1993; 193(1):
420-7.
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