Susana M. Cohen-Cory, Ph.D.

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Office
NPI
Los Angeles, CA 90095
UNITED STATES

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Bio:

Neuronal Development and Differentiation / Growth Factors We are studying how multiple signals such as neuronal growth factors and neural activity interact to influence neuronal development in the visual system of Xenopus laevis. By using a combination of in vivo imaging, cell culture, and molecular techniques we are analyzing how neurotrophins modulate the survival and differentiation of retinal ganglion cells, and how these factors interact with neuronal activity to influence axon arborization and development of synaptic connections between the retina and the optic tectum.

Publications:

Prakash, N., Vanderhaeghen, P., Cohen-Cory, S., Frisen,J., Flanagan, J. G. and Frostig, R. D. Malformation of the functional cortical somatosensory map in adult ephrin-A5 knockout mice revealed by in vivo functional imaging.. Journal of Neuroscience 2000; 20: 5841-5847.

Cohen-Cory, S. BDNF Modulates, But Does Not Mediate, Activity-Dependent Branching and Remodeling of Optic Axon Arbors In Vivo.. Journal of Neuroscience 1999; 19: 9996-10003.

Cohen-Cory, S., Escandon, E. and Fraser,S.E. The cellular patterns of BDNF and trkB expression suggest multiple roles for BDNF during Xenopus visual system development.. Developmental Biology 1996; 179: 102-115.

Cohen-Cory, S. and Fraser, S.E. Effects of brain-derived neurotrophic factor on optic axon branching and remodeling in vivo.. Nature 1995; 378: 192-196.

Lom, B Cogen, J Sanchez, AL Vu, T Cohen-Cory, S Local and target-derived brain-derived neurotrophic factor exert opposing effects on the dendritic arborization of retinal ganglion cells in vivo.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2002; 22(17): 7639-49.

Alsina, B Vu, T Cohen-Cory, S Visualizing synapse formation in arborizing optic axons in vivo: dynamics and modulation by BDNF.. Nature neuroscience. . 2001; 4(11): 1093-101.

Cogen, J Cohen-Cory, S Nitric oxide modulates retinal ganglion cell axon arbor remodeling in vivo.. Journal of neurobiology. . 2000; 45(2): 120-33.

Lom, B Cohen-Cory, S Brain-derived neurotrophic factor differentially regulates retinal ganglion cell dendritic and axonal arborization in vivo.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1999; 19(22): 9928-38.

Prakash, N Cohen-Cory, S Frostig, RD RAPID and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo.. Nature. . 1996; 381(6584): 702-6.

Cohen-Cory, S Fraser, SE BDNF in the development of the visual system of Xenopus.. Neuron. . 1994; 12(4): 747-61.

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