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Work Phone Number:
(310) 206-6141
Work Email Address: jfroines@ucla.edu
Education: Ph.D., Physical-Organic Chemistry,
Yale University
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Dr. Froines' research focuses on 1) Chemical mechanisms and exposure assessment related to the health effects from exposure to airborne particulate matter; 2) Evaluation of toxicokinetic factors in defining and characterizing chemical toxicity; and 3) Risk assessment including pollution prevention. His current research emphasizes the study of etiologic factors in air pollution related health effects, but also includes projects to:
1. Study the role of toxicokinetics, and host factors in the carcinogenicity of arsenic and chromium VI.
2. Develop new approaches to exposure assessment for multi-component systems with a focus on measures of internal dose as characterized by evaluation of metabolites, biomarkers and other toxicological factors. In particular, he leads a research project to investigate pesticide exposure among pesticide applicators, farmworkers, and their families in Mexico.
3. Toxicokinetic modeling to explain toxic interactions between multiple chemicals including studies of enhancement and antagonism. He is currently PI on a project to investigate new approaches to addressing exposure to beryllium metal.
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Professor Froines joined the faculty of the School of Public Health in 1981. He received a B.S. in chemistry from UC Berkeley (1963), M.S. in chemistry (1964) and Ph.D. in physical-organic chemistry (1967) from Yale University. He conducted postdoctoral research at the Royal Institution of Great Britain under Nobel Laureate, Sir George Porter from 1966-68. Before coming to the UCLA School of Public Health, Dr. Froines was Assistant Professor of Chemistry at the University of Oregon and later served as Director of Toxic Substances at the Occupational Safety and Health Administration and Deputy Director of the National Institute for Occupational Safety and Health. Dr. Froines is currently the Director of the Center for Occupational and Environmental Health. He is also the Director of the Southern California Particle Center and Supersite. He is Associate Director of the Southern California Environmental Health Sciences Center and the Director of the UCLA Fogarty Program in Occupational and Environmental Health. Dr. Froines' area of expertise is toxicology and exposure assessment. His research interests are in the qualitative and quantitative characterization of risk factors in environmental and occupational health.
Dr. Froines chairs the State of California's Scientific Review Panel; the central review panel at the State level for identifying toxic air contaminants. He is a member of the National Toxicology Program's Board of Scientific Counselors. He is a member of the Institute of Medicine's Environmental Health Roundtable.
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Hiyoshi K, Takano H, Inoue K, Ichinose T, Yanagisawa R, Tomura S, Cho AK, Froines JR, Kumagai Y Effects of a single intratracheal administration of phenanthraquinone on murine lung..
Journal of applied toxicology : JAT. .
2005; 25(1):
47-51.
AK Di, Stefano E, You Y, Rodriguez CE, Schmitz DA, Kumagai Y, Miguel AH, Eiguren-Fernandez A, Kobayashi T, Avol E, Froines JR Determination of Four Quinones in Diesel Exhaust Particles, SRM 1649a and Atmospheric PM2.5..
Aerosol Science and Technology
2003;
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Sabty-Daily RA, Harris PA, Hinds WC, Froines JR Size distribution and speciation of chromium in paint spray aerosol at an aerospace facility..
The Annals of occupational hygiene. .
2005; 49(1):
47-59.
Sabty-Daily RA, Hinds WC, Froines JR Size distribution of chromate paint aerosol generated in a bench-scale spray booth..
The Annals of occupational hygiene. .
2005; 49(1):
33-45.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage..
Environmental health perspectives. .
2003; 111(4):
455-60.
Okoji RS, Yu RC, Maronpot RR, Froines JR Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice..
Carcinogenesis. .
2002; 23(5):
777-85.
Li N, Kim S, Wang M, Froines J, Sioutas C, Nel A Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter..
Inhalation toxicology. .
2002; 14(5):
459-86.
Yu RC, Hattis D, Landaw EM, Froines JR Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone..
Archives of toxicology. .
2002; 75(11-12):
643-52.
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Work Address:
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21-293 CHS
CAMPUS - 177220
CA
UNITED STATES
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Work Phone Number:
(310) 206-6141
Work Email Address: jfroines@ucla.edu
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