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Work Phone Number:
(310)-825-7545
310-825-6567
Email Address: acho@mednet.ucla.edu
Education: Ph.D.
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Molecular & Medical Pharmacology
Dr. Cho's laboratory utilizes chemical approaches to conduct research in drug metabolism and neuropharmacology. Drug metabolism studies investigate mechanisms of oxidation of foreign compounds by cytochrome P450, an enzyme system capable of oxidizing the carbon atom of a variety of functional groups including ethers, olefins and amines. Since many of the products of this system are pharmacologically or toxicologically active, their formation is important in understanding drug action. The laboratory is also studying the action of central nervous stimulants related to amphetamine. These compounds affect dopaminergic and serotonergic neurons and stimulate the postsynaptic receptor. These studies have used in vivo microdialysis and pharmacokinetic approaches to understand drug action in intact organisms.
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Segal DS, Kuczenski R, O'Neil ML, Melega WP and Cho AK Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge..
Neuropsychopharmacology
2003; 10:
1730-1740.
Cho AK, Melega WP Patterns of methamphetamine abuse and their consequences..
Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. .
2002; 21(1):
21-34.
Cho AK, Melega WP Patterns of methamphetamine abuse and their consequences..
Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. .
2002; 21(1):
21-34.
Cho AK, Melega WP Patterns of methamphetamine abuse and their consequences..
Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. .
2002; 21(1):
21-34.
Cho AK, Melega WP Patterns of methamphetamine abuse and their consequences..
Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. .
2002; 21(1):
21-34.
Narimatsu S, Arai T, Masubuchi Y, Horie T, Hosokawa M, Ueno K, Kataoka H, Yamamoto S, Ishikawa T, Cho AK Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol..
Biol Pharm Bull
2001; 24:
988-94.
Cho AK, Melega WP, Kuczenski R, Segal DS, Schmitz DA Caudate-putamen dopamine and stereotype response profiles after intravenous and subcutaneous amphetamine..
Synapse
1999; 31:
125-133.
Cho AK, Naraimatsu S, Kumagai Y Metabolism of drugs of abuse by cytochromes P450..
Addiction Biology
1999; (in press):
.
Wang MY, Sheu BJ, Berger TW, Young WC, Cho AK Architecture and design of 1-D enhanced cellular neural network processors for signal detection..
Analog Integrated Circuits and Signal Processing
1998; 15:
277-290.
Chu T, Kumagai Y, DiStefano EW, Cho AK Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depiction..
Biochem Pharmacol
1996; 51:
789-796.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage..
Environmental health perspectives. .
2003; 111(4):
455-60.
Ost TW, Munro AW, Mowat CG, Taylor PR, Pesseguiero A, Fulco AJ, Cho AK, Cheesman MA, Walkinshaw MD, Chapman SK Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3..
Biochemistry. .
2001; 40(45):
13430-8.
Cho AK, Melega WP, Kuczenski R, Segal DS Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse..
Synapse (New York, N.Y.) .
2001; 39(2):
161-6.
Melega WP, Cho AK, Schmitz D, Kuczenski R, Segal DS l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine..
The Journal of pharmacology and experimental therapeutics. .
1999; 288(2):
752-8.
Lin LY, Di Stefano EW, Schmitz DA, Hsu L, Ellis SW, Lennard MS, Tucker GT, Cho AK Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6..
Drug metabolism and disposition: the biological fate of chemicals. .
1997; 25(9):
1059-64.
Kuczenski R, Melega WP, Cho AK, Segal DS Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response..
The Journal of pharmacology and experimental therapeutics. .
1997; 282(2):
591-6.
Narimatsu S, Arai T, Watanabe T, Masubuchi Y, Horie T, Suzuki T, Ishikawa T, Tsutsui M, Kumagai Y, Cho AK Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat..
Chemical research in toxicology. .
1997; 10(3):
289-95.
Yamada H, Shiiyama S, Soejima-Ohkuma T, Honda S, Kumagai Y, Cho AK, Oguri K, Yoshimura H Deamination of amphetamines by cytochromes P450: studies on substrate specificity and regioselectivity with microsomes and purified CYP2C subfamily isozymes..
The Journal of toxicological sciences. .
1997; 22(1):
65-73.
Lin LY, Fujimoto M, Distefano EW, Schmitz DA, Jayasinghe A, Cho AK Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine..
The Journal of pharmacology and experimental therapeutics. .
1996; 277(2):
595-603.
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Work Address:
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Office
CHS
Los Angeles, CA 90095
UNITED STATES
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES
23-120 CHS
CAMPUS - 173517
CA
UNITED STATES
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Work Phone Number:
(310)-825-7545
310-825-6567
Email Address: acho@mednet.ucla.edu
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